Monitoring of an Anti-Ulcer Drug Rabeprazole Using Au-Pt Bimetallic Alloy Nanoscale Electrochemical Sensor

Abstract

A new highly selective and sensitive electrochemical sensor has been developed, whereby working electrode is modified with bimetallic Au-Pt alloy nanoparticles (NPs). Au-Pt alloy NPs were prepared by a facile method using non/less toxic chemicals. The optical properties of the synthesized NPs were studied by UV-Visible spectroscopy. The surface structure was characterized by X-ray diffraction and scanning electron microscopy. The NPs were found spherical with an average diameter of 14.6 nm. The electrochemical response of modified electrode with polypyrrole and Au-Pt alloy NPs toward the detection of rabeprazole (antiulcer drug) was systematically investigated though cyclic, square wave and differential pulse voltammetry methods. Under optimized conditions, the developed sensor showed its promise for the trace level (1.29 μM) detection of the analyte. Moreover, the designed sensor demonstrated excellent reproducibility and maintained its integrity in a wide pH range and different supporting electrolytes for the sensing of rabeprazole. The Au-Pt alloy NPs based electrochemical sensor exhibited good selectivity, high sensitivity and stability, fast response time, ease of use and reproducibility.

Ultrasonic Influence on Plasmonic Effects Exhibited by Photoactive Bimetallic Au-Pt Nanoparticles Suspended in Ethanol

“…For example, bimetallic Gold and Platinum NPs (Au-Pt NPs) exhibit two peaks at the linear regime, which make them attractive for suitable catalyst [12] and electrochemical sensors. The formation of bimetallic alloys, such as core-shell and clusters, depends on the structure and size of the core [13], thus, they are widely influenced by the enhancement of the catalytic activity related to SPR effects [14]. Au-Pt NPs have been synthesized by different techniques as simple electrodeposition [15] and environmentally friendly procedures [16]; besides, it has been revealed the possibility to enhance their characteristics by tuning the molar ratios [17].…”

Sonochemically Recovered Aluminum Oxide Nanoparticles from Domestic Aluminum Wastes as a Highly Stable Electrocatalyst for Proton-Pump Inhibitor (Omeprazole) Detection

“…19 Electrochemical biosensors are renowned contestants to quantify the levels of drugs owing to their sensitivity, specificity, fast response and selectivity. [20][21][22][23][24][25][26][27] Recently the reported articles highlighted about electrochemical biosensing of living cell's cofactors, 28 organophosphate pesticides, 29 phenolic compounds, 30 and monitoring of microbial cell viability 31 using cost-effective 32 aluminum modifiers. [33][34][35][36][37] In this article, a novel method for the sensitive and selective detection of OMZ by direct reduction method was reported.…”