Monitoring Neuroinflammation with an HOCl-Activatable and Blood–Brain Barrier Permeable Upconversion Nanoprobe

Zhang, Meng; Zuo, Miaomiao; Wang, Caixia; Li, Zhen; Cheng, Qingyuan; Huang, Ju; Wang, Zijun; Liu, Zhihong

doi:10.1021/acs.analchem.0c00526

Cited by 38 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to monitoring neural activity, rare-earth based nanoparticles can also be used to prepare fluorescent probes for detecting the brain diseases. Liu et al designed HOCl-activated upconversion nanoprobes for visualizing neuroinflammation in vivo 94 . Neuroinflammation is induced by activated microglia and astrocytes, accompanied by a substantial production of HOCl 95 .…”

Section: Rare-earth Based Materials For Early Brain Diseases Monitori...mentioning

confidence: 99%

Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

Zheng

Liu

et al. 2022

Light Sci Appl

View full text Add to dashboard Cite

Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced.

show abstract

Section: Rare-earth Based Materials For Early Brain Diseases Monitori...mentioning

confidence: 99%

Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

Zheng

Liu

et al. 2022

Light Sci Appl

View full text Add to dashboard Cite

show abstract

“…Through MR imaging at 7 T, the noninvasive visual monitoring of cerebral inflammation after ischemic stroke was achieved (Saleh et al, 2004 ). Moreover, Zhang et al ( 2020 ) designed a blood-brain barrier (BBB) permeable and HOCl-activatable upconversion (UC) nanoprobe with NIR emission for the visual study of neuroinflammation (NI) in vivo ( Figure 3A ). Upon intravenous injection into mice, the probe crossed the BBB via low-density lipoprotein receptor related protein (LRP) mediated transcytosis and was then lightened up by overproduced HOCl in an NI process.…”

Section: Nanomaterials-based Diagnosismentioning

confidence: 99%

Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke

Lin

Tang

2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Stroke is a major public health issue, corresponding to the second cause of mortality and the first cause of severe disability. Ischemic stroke is the most common type of stroke, accounting for 87% of all strokes, where early detection and clinical intervention are well known to decrease its morbidity and mortality. However, the diagnosis of ischemic stroke has been limited to the late stages, and its therapeutic window is too narrow to provide rational and effective treatment. In addition, clinical thrombolytics suffer from a short half-life, inactivation, allergic reactions, and non-specific tissue targeting. Another problem is the limited ability of current neuroprotective agents to promote recovery of the ischemic brain tissue after stroke, which contributes to the progressive and irreversible nature of ischemic stroke and also the severity of the outcome. Fortunately, because of biomaterials’ inherent biochemical and biophysical properties, including biocompatibility, biodegradability, renewability, nontoxicity, long blood circulation time, and targeting ability. Utilization of them has been pursued as an innovative and promising strategy to tackle these challenges. In this review, special emphasis will be placed on the recent advances in the study of nanomaterials for the diagnosis and therapy of ischemic stroke. Meanwhile, nanomaterials provide much promise for neural tissue salvage and regeneration in brain ischemia, which is also highlighted.

show abstract

“…data via ultrasonic backscattering to a subcranial receiving device. [520] Beside pure electrical signals recording, neurotransmission also involves electrochemical signal transduction so brain sensing platforms must extend their application to the monitoring of these processes that are conventionally mediated by excitatory or inhibitory neurotransmitters such as glutamate (Glu) and gamma-aminobutyric acid (GABA), confined to the synaptic cleft 460 . [523] However, other neuromodulators such as DA or 5-HT has influence also outside this zone, enabling volume neurotransmission thus influencing multiple cells on a larger area.…”

Section: Electroconductive Platforms To Monitor the Brain Communication Mechanism: Organic Materials Revealing Electrical To Electrochemimentioning

confidence: 99%

“…A successful approach relies on the use of nanosized structures and nanoscale platforms such as NPs as drug transporters, since these have been proved to mediate across the barrier the transport of enzymes and other relevant high molecular weight molecules. [459,460] In this context, amphiphilic polymers, used as coating materials, have endowed permeability and biocompatibility to nanoprobes that thanks to up-conversion nanoparticles and Cy-HOCL dye respond with light emission to HOCL overproduction upon neuroinflammation. [461] However, even if successful strategies allow to cross the barrier, screening of transferred drugs and molecules is still an essential but open challenge, so that different approaches have been used to replicate in vitro the BBB, developing static and dynamic platforms replicating the biological environment to investigate the complex molecular mechanisms regulating the CNS.…”

Section: Blood Brain Barriermentioning

confidence: 99%

Conductive Polymer‐Based Bioelectronic Platforms toward Sustainable and Biointegrated Devices: A Journey from Skin to Brain across Human Body Interfaces

Bettucci

Matrone

Santoro

2021

Adv Materials Technologies

View full text Add to dashboard Cite

the human's body toward medical applications. [1] Coupling electronics with human tissues allows sensing, stimulating and possibly regulating biological functions. On these premises, a key paradigm of bioelectronics is to preserve the functionality of the biological environment upon coupling, in order to "observe biology through non-perturbing lenses". However, aiming to a seamless interface, the properties of common electronic components, based on metals or inorganic semiconductors, have major limitations to comply with the coupling requirements for cells, organs, and tissues. [2] In fact, inorganic materials might display mechanical rigidity (high Young's modulus ≈100 GPa), [3,4] surface degradation phenomena (oxidation) [5] and surface structure which increases interface capacitance. [6,7] Organic materials have so emerged combining mechanical flexibility, compatibility with large area and different surface functionalization processes, while keeping high electrical conductivity and reproducibility. [8,9] Particularly, these materials intrinsically display key properties such as tunable surface roughness, [10] surface chemical reactivity 11 , and Young's moduli ranging from 20 kPa to 3 GPa, [11,12] approaching the modulus of living tissue (10 kPa [13] ). However, the diversity of biological landscapes offered by the different human tissues, in terms of mechanical flexibility, interface functionalization, accessibility and biological activities defines sets of requirements so stringent that commonly for each tissue/organ coupling ad hoc devices and platforms have been developed. Hence, examining the three major human's body interfaces targeted by bioelectronics applications (skin, heart, and brain), this review focuses on the strategies that can be adopted by employing organic materials such as surface patterning, novel material synthesis and bio-functionalization in order to enhance tissue/organ-specific coupling performances. These aspects are investigated highlighting current and future main challenges and providing perspectives on the development of the next generation organic bioelectronics devices, thus envisioning systems that are: 1) able to adapt their interface in shape and size to comply with different curvilinear and hierarchical biological architectures and 2) combine sensing and stimulation to dynamically control biological functions for biomedical applications.

show abstract

Monitoring Neuroinflammation with an HOCl-Activatable and Blood–Brain Barrier Permeable Upconversion Nanoprobe

Cited by 38 publications

References 48 publications

Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke

Conductive Polymer‐Based Bioelectronic Platforms toward Sustainable and Biointegrated Devices: A Journey from Skin to Brain across Human Body Interfaces

Contact Info

Product

Resources

About