Monitoring Methotrexate Therapy in Psoriasis

Reticulosis as a Long-Term Side-Effect of Methotrexate Therapy in a Patient with Generalized Psoriasis and Psoriatic Arthritis

“…In psoriasis the turnover rate of epithelial cells is normalized. Other tissues with a high degree of mitotic activity are affected likewise which leads to the well-known side-effects on bone marrow, oral and gastro-intestinal mucosa and hair matrix [8,12,17,18]. The liver function may also be im paired [3-5, 7, 15, 20], In psoriasis as a benign disease the total dosage is usually kept relatively low and the periods of administration are limited to several weeks or months.…”