Monitoring Electric Current in Biological Tissues by Optical Coherence Tomography

Wawrzyn, Krzysztof; Vuong, Barry; Harduar, Mark K.; Yang, Victor X. D.; Demidov, Valentin; Toronov, Vladislav; Xu, Yuan

doi:10.1364/biomed.2012.bw2a.4

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…The example of phase retrieval from interferogram in Figure 1.13 is shown in Figure 1.15 where phases for each depth layer m were calculated and then unwrapped. The periodic electric field applied to biological tissue in our previously reported onedimensional experiments demonstrated to influence the OCT signal amplitude significantly [54].…”

Section: Optical Coherence Tomographymentioning

confidence: 74%

Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

Demidov¹

2021

Preprint

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This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with optical coherence tomography (OCT). The changes of backscattered OCT signal from tissues were investigated with a low frequency AC electric field being applied to the tissues. Advanced processing algorithms were developed to analyze the amplitude and phase changes of OCT signal. Two-dimensional electrically induced optical changes (EIOC) amplitude and phase images related to the electro-kinetic response of soft tissues were obtained with depth resolution and compared with structural OCT images. The procedure for removing the background noise from EIOC images was introduced.

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Section: Optical Coherence Tomographymentioning

confidence: 74%

Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

Demidov¹

2021

Preprint

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“…It was shown that the surface displacements increased with voltage and were inversely proportional to the frequency of the applied electric field. The periodic electric fields applied to biological tissue in our previous one-dimensional experiments were seen to influence the optical coherence tomography (OCT) signal amplitude significantly, and in synchrony with the applied fields [11]. The detected signal oscillations were likely caused by the field-shifted tissue interstitial fluids, which may change light scattering and absorbance by affecting the mutual alignment of collagen fibrils [12].…”

mentioning

confidence: 99%

Imaging the electro-kinetic response of biological tissues with phase-resolved optical coherence tomography

Demidov¹,

Toronov²,

Xu³

et al. 2014

Photonics &Amp; Lasers in Medicine

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In this study, the electro-kinetic phenomena (EKP) induced in biological tissue by external electric field, while not directly visible in optical coherence tomography (OCT) images, were detected by analyzing their textural speckle features. During application of a low-frequency electric field to the tissue, speckle patterns changed their brightness and shape depending on the local tissue EKP. Since intensities of OCT image speckle patterns were analyzed and discussed in our previous publications, this work is mainly focused on OCT signal phase analysis. The algorithm for extracting local spatial phase variations from unwrapped phases is introduced. The detection of electrically induced optical changes manifest in OCT phase images shows promise for monitoring the fixed charge density changes within tissues through their electro-kinetic responses. This approach may help in the identification and characterization of morphology and function of healthy and pathologic tissues.

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Monitoring Electric Current in Biological Tissues by Optical Coherence Tomography

Cited by 2 publications

References 3 publications

Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography

Imaging the electro-kinetic response of biological tissues with phase-resolved optical coherence tomography

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