Monitoring early developed low bone mineral density in HIV-infected patients by intact parathyroid hormone and circulating fibroblast growth factor 23

Chen, Kuan‐Yu; Wang, Ching-Hsun; Lin, Te‐Yu; Chang, C.; Liu, Changlin; Hsiao, Yung Ting; Hung, Ching-Ching; Wang, Ning‐Chi

doi:10.1016/j.jmii.2018.08.017

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…In terms of bone mineral content (BMC), although a significant difference was observed, in which males presented with higher BMC than females, this can be partially explained by the fact that males had a greater average height when than females. Even with no differences in BMD between sex comparisons, we expected higher values for males than females due to the male's height and the strong association between BMC and BMD (32).…”

Section: Discussionmentioning

confidence: 73%

Frequency of osteopenia and osteoporosis in men and women living with HIV/Aids: an observational study

Aguilar

Santos

Machado

et al. 2021

Medicina (Ribeirão Preto)

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Aims: To identify the frequency in changes of bone metabolism, including below the average value for age, osteopenia, and osteoporosis, in people living with HIV/AIDS (PLWHA) and to compare the frequency of factors associated with bone mineral density (BMD) and body composition between sex. Methods: This observational study assessed 106 PLWHA (65 male) recruited from the University Hospital of Ribeirão Preto Medical School from 2013 to 2014. BMD was measured using Dual Energy X-ray Absorptiometry (DXA). Standard deviation values for Z- and T-score proposed by the International Society for Clinical Densitometry were adopted to classify participants below the average value for age, osteopenia, and osteoporosis. Qui-square and Fischer’s exact tests were employed to compare males and females based on their factors associated with BMD reduction. Results: Fifty-two (49%) PLWHA presented at least one diagnosis for below the average value for age, osteopenia, and osteoporosis, being 37 (57%) and 15 (37%) male and female, respectively. Frequency of alcohol consumption was higher in males (n=20; 30.8%) than females (n=05; 12.2%) (p=0.028). Conclusions: A high rate of PLWHA showed changes in bone metabolism, with a higher frequency in males. The frequency of alcohol consumption was higher in males, and it may partially explain the possible causes of the increased rates of bone metabolism changes observed in this group. This information may help develop strategies for reducing the frequency of diagnosis for below the average value for age, osteopenia, osteoporosis improving quality of life in PLWHA.

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Section: Discussionmentioning

confidence: 73%

Frequency of osteopenia and osteoporosis in men and women living with HIV/Aids: an observational study

Aguilar

Santos

Machado

et al. 2021

Medicina (Ribeirão Preto)

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“…Antiretroviral therapy (ART) is the standard treatment for HIV control and contributes positively to patient's life by prolonging life expectancy, and decreasing the frequency of hospital admissions [2]. However, exposure to HIV and prolonged use of ART are associated with reduced bone mineral density area (aBMD), which increases the risk of osteopenia and osteoporosis in this population [3,4].…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Content Estimation in People Living with HIV: Prediction and Validation of Sex-Specific Anthropometric Models

Correia

Navarro

Cordeiro

et al. 2022

IJERPH

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People living with HIV (PWH) experience an accelerated reduction in bone mineral content (BMC), and a high risk of osteopenia and osteoporosis. Anthropometry is an accurate and low-cost method that can be used to monitor changes in body composition in PWH. To date, no studies have used anthropometry to estimate BMC in PWH. To propose and validate sex-specific anthropometric models to predict BMC in PWH. This cross-sectional study enrolled 104 PWH (64 males) aged >18 years at a local university hospital. BMC was measured using dual energy X-ray absorptiometry (DXA). Anthropometric measures were collected. We used linear regression analysis to generate the models. Cross-validations were conducted using the “leave one out”, from the predicted residual error sum of squares (PRESS) method. Bland–Altman plots were used to explore distributions of errors. We proposed models with high coefficient of determination and reduced standard error of estimate for males (r2 = 0.70; SEE = 199.97 g; Q2PRESS = 0.67; SEEPRESS = 208.65 g) and females (r2 = 0.65; SEE = 220.96 g; Q2PRESS = 0.62; SEEPRESS = 221.90 g). Our anthropometric predictive models for BMC are valid, practical, and a low-cost alternative to monitoring bone health in PWH.

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Serum Levels of Fibroblast Growth Factor 23 in People Living with HIV

Seo

Kitazawa

Ota

2019

CHR

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Background: Fibroblast growth factor (FGF) 23 is a well-known phosphaturic hormone produced mainly by bone cells to maintain phosphate and mineral homeostasis. Serum FGF23 levels are elevated in patients with chronic kidney disease (CKD), and elevated FGF23 might increase the risk of cardiovascular disease (CVD). Several reports have documented an increased incidence of risk factors for osteopenia, CKD, and CVD in people living with HIV (PLWH). However, few reports related to FGF23 in PLWH have been published. Methods: Male HIV patients who presented to the outpatient clinic of Teikyo University Hospital, Tokyo, Japan, in 2015 and were treated with antiretroviral therapy (ART) for > 6 months were enrolled in the study. In addition to serum FGF23 measurements, the clinical factors assessed included age, ART regimens, and laboratory data. Spearman correlation and multiple regression analysis were performed to determine factors significantly associated with FGF23. Results: In total, 67 patients were enrolled in the present study. The median age was 43.7 years, the median CD4 count was 529 cells/μL, and the median serum FGF23 level was 36.0 pg/mL. Based on correlation and multiple regression analyses, serum FGF23 levels were significantly correlated with HIV RNA > 50 copies (correlation analysis: t = 3.4259, P = 0.0011 / multiple regression analysis: P = 0.00106) or abacavir (ABC)/lamivudine (3TC) use (t = 2.8618, P = 0.0057 / P = 0.02704). Conclusions: Factors significantly associated with elevated serum FGF23 levels included poor virologic control and ABC/3TC use.

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Monitoring early developed low bone mineral density in HIV-infected patients by intact parathyroid hormone and circulating fibroblast growth factor 23

Cited by 3 publications

References 40 publications

Frequency of osteopenia and osteoporosis in men and women living with HIV/Aids: an observational study

Frequency of osteopenia and osteoporosis in men and women living with HIV/Aids: an observational study

Bone Mineral Content Estimation in People Living with HIV: Prediction and Validation of Sex-Specific Anthropometric Models

Serum Levels of Fibroblast Growth Factor 23 in People Living with HIV

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