Monitoring cellulose oxidation for protein immobilization in paper-based low-cost biosensors

Imamura, Amanda Hikari; Segato, Thiago Pinotti; Oliveira, Letícia Jordão Marques de; Hassan, Ayaz; Crespilho, Frank N.; Carrilho, Emanuel

doi:10.1007/s00604-020-04250-6

Cited by 20 publications

(16 citation statements)

References 24 publications

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“…The prepared cellulose microgel demonstrated a rapid response within 4 min to glucose at 0.003 M. The response time was found to decrease to only 2 min upon increasing the glucose concentration to 0.005 M as the reaction solution displayed a color change from colorless to yellow. Imamura et al [117] reported recently an oxidation process of a cellulose paper strip, using periodate to introduce an instrument-free colorimetric biosensor for protein quantification in urine with the ability to monitor the levels of proteinuria and microalbuminuria. The improvement of protein incorporation into the oxidized paper was quantified by a Ponceau chromophore-based colorimetric assay.…”

Section: Cellulose-based Colorimetric Biosensorsmentioning

confidence: 99%

Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis

2020

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Cellulose has attracted much interest, particularly in medical applications such as advanced biosensing devices. Cellulose could provide biosensors with enhanced biocompatibility, biodegradability and non-toxicity, which could be useful for biosensors. Thus, they play a significant role in environmental monitoring, medical diagnostic tools, forensic science, and foodstuff processing safety applications. This review summarizes the recent developments in cellulose-based biosensors targeting the molecular design principles toward medical detection purposes. The recognition/detection mechanisms of cellulose-based biosensors demonstrate two major classes of measurable signal generation, including optical and electrochemical cellulosic biosensors. As a result of their simplicity, high sensitivity, and low cost, cellulose-based optical biosensors are particularly of great interest for including label-free and label-driven (fluorescent and colorimetric) biosensors. There have been numerous types of cellulose substrates employed in biosensors, including several cellulose derivatives, nano-cellulose, bacterial cellulose, paper, gauzes, and hydrogels. These kinds of cellulose-based biosensors were discussed according to their preparation procedures and detection principle. Cellulose and its derivatives with their distinctive chemical structure have demonstrated to be versatile materials, affording a high-quality platform for accomplishing the immobilization process of biologically active molecules into biosensors. Cellulose-based biosensors exhibit a variety of desirable characteristics, such as sensitivity, accuracy, convenience, quick response, and low-cost. For instance, cellulose paper-based biosensors are characterized as being low-cost and easy to operate, while nano-cellulose biosensors are characterized as having a good dispersion, high absorbance capacity, and large surface area. Cellulose and its derivatives have been promising materials in biosensors which could be employed to monitor various bio-molecules, such as urea, glucose, cell, amino acid, protein, lactate, hydroquinone, gene, and cholesterol. The future interest will focus on the design and construction of multifunctional, miniaturized, low-cost, environmentally friendly, and integrated biosensors. Thus, the production of cellulose-based biosensors is very important.

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Section: Cellulose-based Colorimetric Biosensorsmentioning

confidence: 99%

Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis

2020

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“…As a result, the effective treatment period is curtailed, leading to serious lesions and a significant deterioration in quality of life [104]. However, recent research has shown that lab-on-paper platforms provide a feasible means of detecting early-stage kidney disease by evaluating the concentrations of creatinine (Cre) and albumin (Alb) [105][106][107][108][109][110][111], micro-albumin and protein [112][113][114][115][116], and uric acid [117][118][119][120][121][122][123] in urine samples.…”

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

“…The results obtained for 12 urine samples collected from a hospital showed that the detection results for the Alb-to-Cre ratio were within 15% of the theoretical values. Micro-albumin and urinary protein measurement also provide a feasible means of performing the early-stage detection of kidney disease [112][113][114]. Cai et al [112] presented a field-amplification lab-on-paper device for the sensitive colorimetric detection of microalbuminuria (MAU) in human urine.…”

Section: Creatinine Albumin Protein and Uric Acid Analysismentioning

confidence: 99%

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

et al. 2021

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In recent years, microfluidic lab-on-paper devices have emerged as a rapid and low-cost alternative to traditional laboratory tests. Additionally, they were widely considered as a promising solution for point-of-care testing (POCT) at home or regions that lack medical infrastructure and resources. This review describes important advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis over the past five years. The review commenced by explaining the choice of paper, fabrication methods, and detection techniques to realize microfluidic lab-on-paper devices. Then, the sample pretreatment procedure used to improve the detection performance of lab-on-paper devices was introduced. Furthermore, an in-depth review of lab-on-paper devices for disease measurement based on an analysis of urine samples was presented. The review concludes with the potential challenges that the future development of commercial microfluidic lab-on-paper platforms for human disease detection would face.

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“…As for the studied objects, the oxidation of pure cellulose (or its low-molecular-weight analogues imitating the properties of cellulose) and paper was studied. Regarding cellulose oxidation processes, those caused and/or catalyzed by "artificial" oxidizing agents such as the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical, periodates, and hydrogen peroxide were followed [30][31][32][33], along with the processes involving atmospheric oxygen and corresponding ROS [34].…”

Section: Oxidation Of Cellulose and Paper In An Alkaline Environmentmentioning

confidence: 99%

Stability of Alum-Containing Paper under Alkaline Conditions

Jablonský

Šíma

2020

Molecules

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The present contribution evaluates the methods of degradation and stabilization of alum-containing paper with a focus on the alkaline environment achieved by deacidification procedures. In terms of reviewed subjects, the contribution focuses on alum-rosin sized paper, which is still used as a carrier of knowledge and information; however, it also mentions cellulose itself and other brands of paper. The contribution summarizes the results on the homogeneity of the distribution of alum and rosin in the paper mass and on the paper surface. It provides the knowledge gained in the field of alkaline hydrolysis and oxidation with special regard to transition metal species. It shows the values of alkaline reserves achieved in the main mass-deacidification processes. On the basis of the acquired knowledge, the contribution emphasizes the procedures of paper stabilization. Criteria of “increased mechanical permanence and lifetime prolongation” adopted to evaluate and compare the efficacy of individual mass-deacidification processes were applied and corresponding data are introduced. The contribution also draws attention to the existence of open issues in the area of paper degradation and stabilization.

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Monitoring cellulose oxidation for protein immobilization in paper-based low-cost biosensors

Cited by 20 publications

References 24 publications

Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis

Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

Stability of Alum-Containing Paper under Alkaline Conditions

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