Mönckeberg's Sclerosis: An Unusual Presentation

Abstract

Calcification of the media of peripheral arteries is referred to as Mönckeberg's sclerosis and occurs commonly in aged individuals. However, it also occurs in younger patients with diabetes mellitus and chronic renal failure. In diabetic patients, medial calcification appears to be a strong independent predictor of cardiovascular mortality. In this report, we have presented a 20 year-old-patient with extensive peripheral artery calcification. The etiology of calcification was not identified. It has been suggested that this was an unusual form of Mönckeberg's sclerosis.

Incidentally detected Monckeberg's sclerosis in a diabetic with coronary artery disease

“…Monckeberg's sclerosis has been described in case reports,3 9–12 as well as several case series 1 8 13–15. Many of these cases required limb and/or penile amputation1 12 calling into question the benign prognosis of this condition.…”

Arteriosclerose de Monckeberg como causa de isquemia crítica de membros inferiores: relato de caso

“…A calcificação da média de Monckeberg é uma condição mais prevalente em pessoas acima de 50 anos e do sexo masculino. Aparentemente, não está associada a outros fatores de risco, embora a incidência seja maior em pacientes diabéticos 1,3,4 . A prevalência na população, em estudo recente, foi de 13,3% no sexo masculino Lehto et al 7 demonstraram, em seu estudo, que a arteriosclerose de Monckeberg é um fator de risco independente para morbimortalidade por eventos cardiovasculares.…”

Mönckeberg's sclerosis – is the artery the only target of calcification?

“…Mönckeberg's sclerosis (MS) is a degenerative and apparently non-inflammatory disease in which the media of small and medium-sized muscular arteries becomes calcified independently of atherosclerosis. Since the condition does not involve primarily the intimal layer of the artery, the lumen is kept open by the rigid media and, therefore, luminal narrowing is not a direct consequence [ 1 - 4 ]. Recent studies, however, have demonstrated that MS is a risk factor for cardiovascular disease and peripheral artery obstruction [ 1 , 4 , 5 ].…”