“…Arteriosclerosis is generally classified into the following two patterns: (i) atherosclerosis having plaque lesions in the intima; and (ii) Mönckeberg's arteriosclerosis having calcification in the media with or without involvement of the internal elastic [14][15][16]. In the clinical setting, Mönckeberg's atherosclerosis is frequently identified from inspection of conventional X-ray images of the pelvis or lower extremities [14] and has also been observed in arteries of various organs (coronary arteries [17], temporal arteries [18], lingual artery, facial artery [19], carotid artery [19], uterus [20], breasts [21][22][23], and the upper extremities [24]). Although Mönckeberg's atherosclerosis in various organs has been thoroughly investigated, there has been a paucity of research published on intracranial Mönckeberg's atherosclerosis.…”
Cerebral infarction (CI) severely affects the prognosis of patients with malignancy. The aim of the study was to compare the pathology of CI between cases with and without malignancy focusing on intracranial Mönckeberg’s atherosclerosis. Among 778 autopsy cases of craniotomy, 53 cases of “cerebral infarction without malignancy group” (CI group), 50 cases of “malignant tumor without CI group” (MT group), and 39 cases of “cerebral infarction with malignancy group” (CM group) were identified. Mönckeberg’s atherosclerosis was mainly found in the basal ganglia and its prevalence in the CM group (38.5%) was significantly higher than in the MT group (12.0%, p = 0.005), and apparently higher than in the CI group (18.9%, p = 0.057). The CI group was significantly older, had higher BMIs, and a greater prevalence of hypertension and atrial fibrillation compared to the CM group. In addition, the prevalence of chronic renal disease was significantly lower in the CM group (2.6%, p = 0.012) than in the CI group (20.8%). Our results indicated that Mönckeberg’s atherosclerosis was often found in the basal ganglia of CM cases and that intracranial Mönckeberg’s atherosclerosis is a potential risk factor for CI in patients with advanced stage malignancy.
“…Arteriosclerosis is generally classified into the following two patterns: (i) atherosclerosis having plaque lesions in the intima; and (ii) Mönckeberg's arteriosclerosis having calcification in the media with or without involvement of the internal elastic [14][15][16]. In the clinical setting, Mönckeberg's atherosclerosis is frequently identified from inspection of conventional X-ray images of the pelvis or lower extremities [14] and has also been observed in arteries of various organs (coronary arteries [17], temporal arteries [18], lingual artery, facial artery [19], carotid artery [19], uterus [20], breasts [21][22][23], and the upper extremities [24]). Although Mönckeberg's atherosclerosis in various organs has been thoroughly investigated, there has been a paucity of research published on intracranial Mönckeberg's atherosclerosis.…”
Cerebral infarction (CI) severely affects the prognosis of patients with malignancy. The aim of the study was to compare the pathology of CI between cases with and without malignancy focusing on intracranial Mönckeberg’s atherosclerosis. Among 778 autopsy cases of craniotomy, 53 cases of “cerebral infarction without malignancy group” (CI group), 50 cases of “malignant tumor without CI group” (MT group), and 39 cases of “cerebral infarction with malignancy group” (CM group) were identified. Mönckeberg’s atherosclerosis was mainly found in the basal ganglia and its prevalence in the CM group (38.5%) was significantly higher than in the MT group (12.0%, p = 0.005), and apparently higher than in the CI group (18.9%, p = 0.057). The CI group was significantly older, had higher BMIs, and a greater prevalence of hypertension and atrial fibrillation compared to the CM group. In addition, the prevalence of chronic renal disease was significantly lower in the CM group (2.6%, p = 0.012) than in the CI group (20.8%). Our results indicated that Mönckeberg’s atherosclerosis was often found in the basal ganglia of CM cases and that intracranial Mönckeberg’s atherosclerosis is a potential risk factor for CI in patients with advanced stage malignancy.
“…In 2012, a case report was published in The Journal of Obstetrics and Gynecology of India describing MocA in the uterine vessels, discovered following a vaginal hysterectomy. 6 A possible association between MocA and CE remains undetermined. Most studies regarding CE consider the inflammatory condition in the context of recurrent pregnancy loss or repeated failure of implantation during in vitro fertilization.…”
Section: Discussionmentioning
confidence: 99%
“…The prevalence of MocA is thought to be generally increased in the postmenopausal population due to age, although few reports describe the involvement of the uterine vessels 5,6 . In 2012, a case report was published in The Journal of Obstetrics and Gynecology of India describing MocA in the uterine vessels, discovered following a vaginal hysterectomy 6 . A possible association between MocA and CE remains undetermined.…”
Section: Discussionmentioning
confidence: 99%
“…4 The frequency at which uterine vessels are involved by MocA is unknown. 5,6 We know that there is an increased prevalence of MocA in postmenopausal women based on age alone; the question becomes what effects this condition may have on their reproductive organs, if any. Novotny et al 5 proposed that the resulting rigidity of arterial walls from MocA can lead to longterm poor perfusion of the uterus.…”
Section: Introductionmentioning
confidence: 99%
“…MocA characteristically occurs in peripheral vessels 4 . The frequency at which uterine vessels are involved by MocA is unknown 5,6 . We know that there is an increased prevalence of MocA in postmenopausal women based on age alone; the question becomes what effects this condition may have on their reproductive organs, if any.…”
Objective: Chronic endometritis is rarely reported in the postmenopausal population. Here, we describe a case of chronic endometritis in a patient who had undergone premature menopause that was later found to have Monckeberg arteriosclerosis (MocA) of the uterine vessels.Methods: A review of the literature revealed a single report of MocA affecting the uterine vessels and no reports in a patient who had undergone premature menopause. A case of a 69-year-old presenting with postmenopausal bleeding and having the diagnosis of chronic endometritis is described.Results: Following definitive management with hysterectomy, final histopathology showed MocA of the uterine vessels.Conclusions: The lack of reviews of chronic endometritis in postmenopausal women reveals a gap in the literature. Further studies are necessary to review MocA and decreased uterine perfusion in the context of a possible predisposition to chronic endometrial infection and/or inflammation.
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