In the tectonic framework of the seismically active Tian Shan, the Jiashi‐Keping region, located at the mountain's southwestern front, is characterized by frequent moderate (M 5.5–7.0) earthquakes, rather than by strong (M ≥ 7.5) earthquakes as observed in other Tian Shan regions. What structures are responsible for these moderate earthquakes and whether or not more destructive earthquakes can occur remain largely unexplored. Based on an integrated analysis of published geologic and geomorphic mapping data, Google Earth satellite images, published and our collected 2D petroleum seismic‐reflection profiles, as well as available seismologic data and InSAR observations, in this study, we investigate active structural geometries and their correlation with the 2020 Mw 6.0, the 2003 Mw 6.2, and other recorded major earthquakes. Our study indicates that active structures in the region can be grouped into the Kepintagh thrust imbricates, the Bachu‐Kepintagh transpressional fault system, and the Xiasuhong transtensional fault system. The recorded major earthquakes are correlated with the Kepintagh thrust imbricates and the Xiasuhong fault system, both of which are highly segmented along strike and have limited downdip extensions. Although the recorded seismicity is characterized by moderate earthquakes, larger earthquakes may be generated by (i) the Bachu transpressional fault system (Mw ≥ 7.3) and the Kepintagh lower ramp (Mw > 7.5). Our study highlights the control of fault geometry on the seismic rupture process and regional seismic activities and enhances our understanding of seismic hazards in the Tian Shan.