Molybdenum disulfide-based hyaluronic acid-guided multifunctional theranostic nanoplatform for magnetic resonance imaging and synergetic chemo-photothermal therapy

Liu, Jian; Zheng, Junxia; Nie, Huifang; Zhang, Doudou; Cao, Dairong; Xing, Zhen; Li, Bifei; Lee, Jia

doi:10.1016/j.jcis.2019.04.022

Cited by 35 publications

(24 citation statements)

References 52 publications

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“…Moreover, EGFR can specically bind to monoclonal antibodies EGFRmAb (Cetuximab, CET) 45,46 to achieve internalization. In addition, as a tyrosine kinase receptor, EGFR can be inhibited by corresponding small molecule inhibitors, such as getinib 47,48 and erlotinib. 49,50 Both monoclonal antibodies and inhibitors inhibit EGFR-mediated downstream signalling when providing targeting capabilities.…”

Section: "Intracellular Targets"mentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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Section: "Intracellular Targets"mentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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“…[ 303–305 ] In a recently developed MoS 2 ‐based multifunctional nanotheranostic system, HA‐grafted MoS 2 nanosheets served as a platform to carry Gd‐based contrast agents and the anticancer drug gefitinib; they also acted as photoabsorbing agent to induce photothermal ablation of tumors. [ 306 ] In vivo results demonstrated inhibition of tumor growth that was mediated by the synergistic effects of photothermal ablation and chemotherapy through blockage of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling pathway. Although most of the preclinical theranostic systems using functionalized‐TMDCs have demonstrated enhanced stabilities, there are reports suggesting the disturbance of cell homeostasis by 2D TMDCs.…”

Section: Preclinical Status Of Nanotheranostic Systems: Update On Animal Studiesmentioning

confidence: 99%

Preclinical Cancer Theranostics—From Nanomaterials to Clinic: The Missing Link

Johnson

Koshy

Yang

et al. 2021

Adv Funct Materials

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Nanomaterials with cancer‐imaging and therapeutic properties have emerged as the principal focus of nanotheranostics. The past decade has experienced a significant increase in research in the design, formulation, and preclinical and clinical trials of theranostic nanosystems. However, current theranostic nanoformulations have yet to be approved by the FDA for clinical use. Consequently, the present review focuses on the importance of the careful examination of the in vivo preclinical status of specific nanotheranostic materials as a prerequisite for their clinical translation. The scope of coverage is structured according to all of the major organic, inorganic, 2D, and hybrid nanotheranostic materials and their in vivo preclinical status. The therapeutic advantages and limitations of these materials in animal models are considered and the various strategies to enhance the biocompatibility of theranostic nanoparticles are summarized.

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“…In addition to thin, flexible, and strong characteristics, TMDs are excellent optical absorbers, thus producing photolimunescence and photothermal effects [66][67][68][69]. TMDs can be formed with various materials including molybdenum disulfide (MoS 2 ) [70][71][72][73], tungsten disulfide (WS 2 ) [74][75][76][77], and molybdenum diselenide (MoSe 2 ) [78][79][80]. Transition metal oxides (TMOs) are compounds of oxygen atoms and transition metals such as titanium (TiO 2 ) [81,82] and manganese (MnO 2 ) [83][84][85].…”

Section: Types and Characteristicsmentioning

confidence: 99%

Recent Trends in Photoacoustic Imaging Techniques for 2D Nanomaterial-Based Phototherapy

et al. 2021

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A variety of 2D materials have been developed for therapeutic biomedical studies. Because of their excellent physicochemical properties, 2D materials can be used as carriers for delivering therapeutic agents into a lesion, leading to phototherapy. Various optical imaging techniques have been used for the monitoring of the treatment process. Among these, photoacoustic imaging has unique advantages including relatively deep imaging depth and large field of view with high spatial resolution. In this review article, we summarize the types of photoacoustic imaging systems used for phototherapy monitoring, then we explore contrast-enhanced photoacoustic images using 2D materials. Finally, photoacoustic image-guided phototherapies are discussed. We conclude that 2D material-based phototherapy can be efficiently monitored by photoacoustic imaging techniques.

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Molybdenum disulfide-based hyaluronic acid-guided multifunctional theranostic nanoplatform for magnetic resonance imaging and synergetic chemo-photothermal therapy

Cited by 35 publications

References 52 publications

Dual-targeted photothermal agents for enhanced cancer therapy

Dual-targeted photothermal agents for enhanced cancer therapy

Preclinical Cancer Theranostics—From Nanomaterials to Clinic: The Missing Link

Recent Trends in Photoacoustic Imaging Techniques for 2D Nanomaterial-Based Phototherapy

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