Molluscum contagiosum virus infection

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care

“…Molluscum contagiosum (MC) is a common skin condition that predominantly affects children, 1 and is one of the 50 most prevalent diseases globally. 2 MC typically presents as one or more umbilicated, smooth, fleshcoloured, dome-shaped lesions, 3 and is usually diagnosed on clinical examination by a GP or dermatologist.…”

Innate immune activation of NFκB and its antagonism by poxviruses

“…Despite this, most poxviruses can at least enter a wide variety of cells from many different animal species in a fashion that is mostly independent of species-specific receptors, but rather involves virion proteins that are conserved in all poxviruses [6]. However some poxviruses are incapable of replicating in hosts or even cells to which they are not strictly adapted, such as MCV which only appears to efficiently infect human keratinocytes [7].…”

“…TNF is particularly important in controlling MCV infections as evidenced by the exacerbation and spread of lesions in patients taking anti-TNF therapy [7], which is reflected in the immune evasion proteins known to be expressed by MCV: MC159 and MC160 block TNF receptor induced apoptosis and NFkB activation by distinct mechanisms [37]. As yet only 5 out of 182 MCV ORFs have been shown to possess immunomodulatory function and these all use strategies not employed by other poxviruses.…”

Development and validation of the Molluscum Contagiosum Diagnostic Tool for Parents: diagnostic accuracy study in primary care

“…Molluscum contagiosum (MC) is a common skin condition that affects people of all ages, but is most prominent in children and the immunocompromised, [1][2][3][4][5] and is one of the 50 most prevalent diseases globally. 6 In children, MC is typically diagnosed in primary care following a clinical examination by a GP.…”