2013
DOI: 10.1016/s1473-3099(13)70109-9
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Molluscum contagiosum virus infection

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Cited by 194 publications
(227 citation statements)
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References 135 publications
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“…Molluscum contagiosum (MC) is a common skin condition that predominantly affects children, 1 and is one of the 50 most prevalent diseases globally. 2 MC typically presents as one or more umbilicated, smooth, fleshcoloured, dome-shaped lesions, 3 and is usually diagnosed on clinical examination by a GP or dermatologist.…”
Section: Introductionmentioning
confidence: 99%
“…Molluscum contagiosum (MC) is a common skin condition that predominantly affects children, 1 and is one of the 50 most prevalent diseases globally. 2 MC typically presents as one or more umbilicated, smooth, fleshcoloured, dome-shaped lesions, 3 and is usually diagnosed on clinical examination by a GP or dermatologist.…”
Section: Introductionmentioning
confidence: 99%
“…Despite this, most poxviruses can at least enter a wide variety of cells from many different animal species in a fashion that is mostly independent of species-specific receptors, but rather involves virion proteins that are conserved in all poxviruses [6]. However some poxviruses are incapable of replicating in hosts or even cells to which they are not strictly adapted, such as MCV which only appears to efficiently infect human keratinocytes [7].…”
Section: Poxviruses and Innate Immunitymentioning
confidence: 99%
“…TNF is particularly important in controlling MCV infections as evidenced by the exacerbation and spread of lesions in patients taking anti-TNF therapy [7], which is reflected in the immune evasion proteins known to be expressed by MCV: MC159 and MC160 block TNF receptor induced apoptosis and NFkB activation by distinct mechanisms [37]. As yet only 5 out of 182 MCV ORFs have been shown to possess immunomodulatory function and these all use strategies not employed by other poxviruses.…”
Section: Poxviral Targeting Of Pro-inflammatory Cytokinesmentioning
confidence: 99%
“…Molluscum contagiosum (MC) is a common skin condition that affects people of all ages, but is most prominent in children and the immunocompromised, [1][2][3][4][5] and is one of the 50 most prevalent diseases globally. 6 In children, MC is typically diagnosed in primary care following a clinical examination by a GP.…”
Section: Introductionmentioning
confidence: 99%