Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care

Olsen, Jonathan; Piguet, Vincent; Gallacher, John; Francis, Nick

doi:10.3399/bjgp15x688093

Cited by 29 publications

(21 citation statements)

References 33 publications

(32 reference statements)

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“…However, studies on this subject are controversial. Some studies have found an increased risk of MC in patients with AD,23,24 with prevalence rates of AD in patients with MC of up to 62% 6,25. It has even been postulated an increased risk of MCV infection in patients with AD and filaggrin mutation 26.…”

Section: Etiology and Epidemiologymentioning

confidence: 99%

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Meza‐Romero¹,

Navarrete‐Dechent²,

Downey³

2019

CCID

131

115

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Molluscum contagiosum (MC) is a self-limited infectious dermatosis, frequent in pediatric population, sexually active adults, and immunocompromised individuals. It is caused by molluscum contagiosum virus (MCV) which is a virus of the Poxviridae family. MCV is transmitted mainly by direct contact with infected skin, which can be sexual, non-sexual, or autoinoculation. Clinically, MC presents as firm rounded papules, pink or skin-colored, with a shiny and umbilicated surface. The duration of the lesions is variable, but in most cases, they are self-limited in a period of 6-9 months. The skin lesions may vary in size, shape, and location, which is more frequent in immunosuppressed patients, and could present complications such as eczema and bacterial superinfection. The diagnosis is based on clinical findings. A useful clinical tool is dermoscopy. If the diagnostic doubt persists, confocal microscopy or skin biopsy could be performed. The need for active treatment for MC is controversial; however, there is a consensus that it should be indicated in cases of extensive disease, associated with complications or aesthetic complaints. There are several treatment modalities which include mechanical, chemical, immunomodulatory, and antivirals. The objective of this article is to review the current evidence in etiology, clinical manifestations, diagnosis, and management alternatives of MC.

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Section: Etiology and Epidemiologymentioning

confidence: 99%

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Meza‐Romero¹,

Navarrete‐Dechent²,

Downey³

2019

CCID

131

115

View full text Add to dashboard Cite

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“…Early electron microscopy of MCV showed preferential infection of keratinocytes in the basal layers at the outset of primary infection ( 63 , 64 ). Similar to other viruses with tropism to the basal layer, micro-abrasions in the skin provide MCV a direct pathway of entry, and it has been well documented that individuals with skin barrier defects have increased susceptibility ( 65 , 66 ). Viral proliferation then continues in mitotically active keratinocytes and expands apically, giving rise to distinct dome-shaped papules called molluscum bodies.…”

Section: Classical Skin-tropic Virusesmentioning

confidence: 99%

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion

et al. 2020

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The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the course and severity of infection. We review the current literature pertaining to the mechanisms of cutaneous viral invasion for classical skin-tropic, oncogenic, and vector-borne skin viruses. We discuss the skin's evolved mechanisms for innate immune viral defense against these invading pathogens, as well as unique strategies utilized by the viruses to escape immune detection. We additionally explore the roles that demographic and environmental factors, such as age, biological sex, and the cutaneous microbiome, play in altering the host immune response to viral threats.

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“…Interestingly, it also facilitates viral entry into the cells. It may be one of the reasons why patients with AD are predisposed to infections with pathogens such as Molluscum contagiosum or Herpesviridae (increased incidence of eczema herpeticum) [ 42 , 72 , 75 ].…”

Section: α-Toxinmentioning

confidence: 99%

Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?

Blicharz

Rudnicka

Samochocki

2019

pdia

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Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococcus aureus. Virulence factors of S. aureus (e.g. superantigens, α- and δ-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition are being elaborated and may enter clinical practice in the future.

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Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care

Cited by 29 publications

References 33 publications

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion

Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?

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