Molluscicidal activities of curcumin-nisin polylactic acid nanoparticle on Biomphalaria pfeifferi

Omobhude, Michael E.; Morenikeji, Olajumoke A.; Oyeyemi, Oyetunde T.

doi:10.1371/journal.pntd.0005855

Cited by 40 publications

(34 citation statements)

References 30 publications

(39 reference statements)

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“…In addition, CUR has been shown to present schistosomicidal activity against adult worms of Schistosoma species and S. japonicum cercariae . Taking into account CUR molluscicidal activity, it was previously also shown that curcumin‐nisin polylactic acid nanoparticles have both moderate molluscicidal activity against Biomplalaria pfeifferi adult and juvenile snails, and lower activity against embryos . However, this previous study did not compare the observed effects of the free CUR compound, as done in this study.…”

Section: Introductionmentioning

confidence: 70%

“…Thus, this study demonstrated that CUR possesses potential activity against B. glabrata embryos with a LC 50 value of 6.54 μg mL −1 and causes mortality of newborn and adult snails (LC 50 values of 42.29 μg mL −1 and 87.69 μg mL −1 , respectively). In contrast, the curcumin‐nisin polylactic acid nanoparticle formulation showed susceptibility dependent on the development stages of the B. pfeifferi snail . This report showed that against adult snails (5–6 weeks), the LC 50 value of the curcumin‐nisin polylactic acid nanoparticle formulation was 339.1 ppm (μg mL −1 ) and against embryos (blastula) it was 4279.5 ppm (μg mL −1 ) .…”

Section: Discussionmentioning

confidence: 85%

“…Strategies that search for alternative compounds that are cheaper and present lower toxicity to non‐targeted organisms are an important approach to intensifying control measures to eliminate or decrease the aquatic stages and the invertebrate host of schistosome life cycle . In this context, the decision to investigate CUR was triggered by a previous study employing the formulation of a curcumin‐nisin polylactic acid nanoparticle, which demonstrated moderate molluscicidal activity against adult and juvenile B. pfeifferi snails and lower activity against embryos . In addition, CUR possesses in vitro activity against adult worms of Schistosoma species and S. japonicum cercariae, exhibits in vivo schistosomicidal activity against S. mansoni and induces immunomodulation of granulomatous inflammation and haspotential antifibrotic activity, reinforcing the potential role of this compound against schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, it can be suggested that the higher activity of free CUR against embryos when compared to the formulation could be attributed to higher ability of the compound to penetrate the membrane (formed by a perivitelinic compound rich in lipids, proteins and glycogen) that protects and nourishes the embryos . It can also be suggested that the lower activity of the formulation against embryos and snails could be due to lower CUR release from the nanoparticle formulation (with a release of around 12% of curcumin‐nisin in 100 h) . In this context, the use of free CUR may confer an advantage over the use of the curcumin‐nisin polylactic acid nanoparticle formulation, as employed in the reported study .…”

Section: Discussionmentioning

confidence: 99%

“…The pre‐hatched eggs were further examined for the number of embryos hatched. The egg hatchability was calculated as the percentage difference relative to the total number of exposed eggs …”

Section: Methodsmentioning

confidence: 99%

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Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Matos

Silva

Paula

et al. 2019

Pest Management Science

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BACKGROUND Schistosomiasis control in endemic areas depends on several factors, including chemotherapy, snail control and adequate sanitation. In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from Curcuma longa, against snails and embryos of Biomphalaria glabrata, which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of Schistosoma mansoni. RESULTS CUR presented high activity against B. glabrata embryos and moderate activity against newborn and adult snails. The lethal concentration (LC50) values after being exposed for 24 h and evaluated for 7 days were 6.54 (95% confidence interval (CI) 5.86–7.30) μg mL−1 for the embryos and 42.29 (95% CI 33.82–52.87) μg mL−1 and 87.69 (95% CI 68.82–111.7) μg mL−1 for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC50 values lower than 10 μg mL−1 at 1, 3, 6, 9 and 12 h, respectively. CONCLUSION Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Matos

Silva

Paula

et al. 2019

Pest Management Science

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Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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