Molluscicidal and cercaricidal activities of curcumin on <i>Biomphalaria glabrata</i> and <i>Schistosoma mansoni</i> cercariae

Matos, Jaqueline Lopes; Silva, Karen Ramos da; Paula, Lucas Antônio de Lima; Cunha, Wilson Roberto; Ramos, Salvador Boccaletti; Rodrigues, Vanderlei; Cabral, Fernanda Janku; Magalhães, Lizandra Guidi

doi:10.1002/ps.5631

Cited by 19 publications

(14 citation statements)

References 45 publications

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“…sylvestris extract eliminated 100 % of the worms after incubation for 72 and 48 h, respectively. On the other hand, at 12.5, 25, and 50 μg/mL ( Table 3), the extract reduced parasite viability moderately; that is, they displayed moderate schistosomidal activity [25,26] . Nevertheless, the var.…”

Section: Resultsmentioning

confidence: 97%

In Vitro Schistosomicidal Activities of the Leaf Extracts from Casearia sylvestris Varieties

Santos

Carvalho

Silva

et al. 2022

Chemistry & Biodiversity

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Schistosomiasis, a tropical disease caused by flatworms, may affect the liver, spleen, bladder, and intestine. Casearia sylvestris Swartz, a medicinal plant, displays antiprotozoal, antimicrobial, antifungal, and antiulcer activities. We have evaluated the in vitro schistosomicidal activity of two C. sylvestris varieties against Schistosoma mansoni adult worms at concentrations between 12.5 and 200 μg/mL. At 100 and 200 μg/mL, the ethanolic C. sylvestris var. sylvestris leaf extract enriched in casearin‐like diterpenes eliminated 100 % of the parasites after incubation for 72 h and 48 h, respectively, whilst the same extract at 200 μg/mL eliminated 96 %, 100 %, and 100 % of the parasites after incubation for 24, 48, and 72 h, respectively. On the other hand, the hydroalcoholic C. sylvestris var. lingua leaf extract at 200 μg/mL eliminated 60.4 and 66.7 % of the parasites after incubation for 48 and 72 h, respectively. The presence of casearin‐like diterpenes and glycosylated flavonoids was confirmed based on chromatographic techniques and mass spectrometry data.

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Section: Resultsmentioning

confidence: 97%

In Vitro Schistosomicidal Activities of the Leaf Extracts from Casearia sylvestris Varieties

Santos

Carvalho

Silva

et al. 2022

Chemistry & Biodiversity

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“…Jia et al (2019) documented that the pentacyclic triterpenoid saponin derived from Camellia oleifera has molluscicidal activity against Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus. Matos et al (2020) proved that the curcumin extract has molluscicidal activity against Biomphalaria glabrata and stated that the embryo development, egg hatching and fecundity rate of adult snails were decreased.…”

Section: Discussionmentioning

confidence: 99%

“…However, experiments have been proven toxic to non-target organisms such as fish (Lemma, 1970). Matos et al (2020) found a fatal effect of curcumin on snails (Biomphalaria glabrata) and cercariae in Schistosoma mansoni.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of molluscicidal, miracicidal and cercaricidal activities of crude aqueous extracts of Origanum majorana, Ziziphus spina-christi and Salvia fruticosa on Schistosoma mansoni and Schistosoma haematobium

El-Nour¹

2021

Egypt. J. of Aquatic Biolo. and Fish.

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Schistosomiasis has been classified as a category II disease after malaria in importance as a targeted tropical disease. Praziquantel (PZQ) which is the chemotherapeutic agent of choice against adult worms, already faces drawback of drug resistance in some Schistosoma isolates. Therefore, searching for new alternative drugs has been the intention of many researchers. In the current study, the effect of different doses 6.25, 12.5, 25. 50. 100 and 200 mg/ml of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa extracts on the snails Bulinus truncatus of the S. haematobium and Biomphalaria alexandrina of the Schistosoma mansoni as well as on the free-living stages miracidia, in addition, the cercariae for both Egyptian species of schistosomes were studied. The results declared that Origanum majorana, Ziziphus spina-christi showed efficacy against snails (molluscicidal), miracidia (miracicidal), and cercariae (cercaricidal) for both Egyptian species of schistosomes in the in vitro, while Salvia fruticosa was less effective than the previous ones.

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“…In a context of schistosomiasis elimination goal, the characterization of biological activities from plant-derived compounds mainly focuses on molluscicidal toxicity to break the parasite transmission cycle. However, some promising candidates present a dual activity by causing either the death of infective larvae [ 16 , 17 , 65 – 67 ] or developmental abnormalities leading to a low pathogenicity [ 68 ]. Mortality values after being exposed only for 24 h at 0.5 ppm were around 75% and 95% for miracidia and cercarciae, respectively, and close to 100% for both after 4 h exposure.…”

Section: Discussionmentioning

confidence: 99%

Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact

et al. 2020

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Background Freshwater snails are the intermediate hosts of a large variety of trematode flukes such as Schistosoma mansoni responsible for one of the most important parasitic diseases caused by helminths, affecting 67 million people worldwide. Recently, the WHO Global Vector Control Response 2017–2030 (GVCR) programme reinforced its message for safer molluscicides as part of required strategies to strengthen vector control worldwide. Here, we present the essential oil from Eryngium triquetrum as a powerful product with molluscicide and parasiticide effect against S. mansoni and the snail intermediate host Biomphalaria glabrata. Methods In the present study, we describe using several experimental approaches, the chemical composition of E. triquetrum essential oil extract and its biological effects against the snail B. glabrata and its parasite S. mansoni. Vector and the free-swimming larval stages of the parasite were exposed to different oil concentrations to determine the lethal concentration required to produce a mortality of 50% (LC50) and 90% (LC90). In addition, toxic activity of this essential oil was analyzed against embryos of B. glabrata snails by monitoring egg hatching and snail development. Also, short-time exposure to sublethal molluscicide concentrations on S. mansoni miracidia was performed to test a potential effect on parasite infectivity on snails. Mortality of miracidia and cercariae of S. mansoni is complete for 5, 1 and 0.5 ppm of oil extract after 1 and 4 h exposure. Results The major chemical component found in E. triquetrum oil determined by GC-FID and GC/MS analyses is an aliphatic polyacetylene molecule, the falcarinol with 86.9–93.1% of the total composition. The LC50 and LC90 values for uninfected snails were 0.61 and 1.02 ppm respectively for 24 h exposure. At 0.5 ppm, the essential oil was two times more toxic to parasitized snails with a mortality rate of 88.8 ± 4.8%. Moderate embryonic lethal effects were observed at the concentration of 1 ppm. Severe surface damage in miracidia was observed with a general loss of cilia that probably cause their immobility. Miracidia exposed 30 min to low concentration of plant extract (0.1 ppm) were less infective with 3.3% of prevalence compare to untreated with a prevalence of 44%. Conclusions Essential oil extracted from E. triquetrum and falcarinol must be considered as a promising product for the development of new interventions for schistosomiasis control and could proceed to be tested on Phase II according to the WHO requirements.

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Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Cited by 19 publications

References 45 publications

In Vitro Schistosomicidal Activities of the Leaf Extracts from Casearia sylvestris Varieties

In Vitro Schistosomicidal Activities of the Leaf Extracts from Casearia sylvestris Varieties

Evaluation of molluscicidal, miracicidal and cercaricidal activities of crude aqueous extracts of Origanum majorana, Ziziphus spina-christi and Salvia fruticosa on Schistosoma mansoni and Schistosoma haematobium

Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact

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