Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate <i>Didemnum molle</i>

Donia, Marwa S.; Wang, Bin; Dunbar, D. Chuck; Desai, Prashant; Patny, Akshay; Avery, Mitchell A.; Hamann, Mark T.

doi:10.1021/np700718p

Cited by 87 publications

(47 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mollamide B exhibited moderate antimalarial activity against P. falciparum (D6 clone and W2 clone), with IC 50 values of 2.0 and 2.1 μg/mL, respectively. Further, mollamide B also exhibited marginal activity against Leishmania donovani , with IC 50 and IC 90 values of 18 and 35 μg/mL, respectively, and against HIV-1 in human PBM cells with an EC 50 value of 48.7 μM [ 83 ].…”

Section: Anti-infective Marine Peptidesmentioning

confidence: 99%

Marine Peptides and Their Anti-Infective Activities

2015

View full text Add to dashboard Cite

Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.

show abstract

Section: Anti-infective Marine Peptidesmentioning

confidence: 99%

Marine Peptides and Their Anti-Infective Activities

2015

View full text Add to dashboard Cite

show abstract

“…Mollamide from Didemnum molle was cyclodepsipeptide and showed cytotoxicity in P388 murine leukemia cells (IC 50 values of 1 μg/mL) and in A549 human lung carcinoma and HT29 human colon carcinoma cells (2.5 μg/mL) ( Figure 40 ) [ 128 , 129 ]. Among these, mollamide B ( 90 ) showed significant percent growth inhibition at 100 μM in the H460 non-small cell lung cancer cell, MCF7 breast cancer cell, and SF-268 CNS cancer cell line, but the National Cancer Institute (NCI) 60-cell line panel lacked tumor cell selectivity [ 130 ]. In contrast to mollamide B, mollamide C ( 91 ) showed strong in vitro cytotoxicity against leukemias (L1210 and CCRF-CEM), solid tumors (38, HCT-116, H125, MCF-7, and LNCaP), and a human normal cell (hematopoietic progenitor cell, CFU-GM); this was observed using a disk diffusion assay.…”

Section: Bioactive Peptides With Anticancer Potential Isolated Fromentioning

confidence: 99%

“…In contrast to mollamide B, mollamide C ( 91 ) showed strong in vitro cytotoxicity against leukemias (L1210 and CCRF-CEM), solid tumors (38, HCT-116, H125, MCF-7, and LNCaP), and a human normal cell (hematopoietic progenitor cell, CFU-GM); this was observed using a disk diffusion assay. The results showed that the leukemia and normal cells were slightly toxic but showed a larger difference in the solid tumor group [ 130 ].…”

Section: Bioactive Peptides With Anticancer Potential Isolated Fromentioning

confidence: 99%

Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides

Kang

Choi

Seo

et al. 2018

IJMS

View full text Add to dashboard Cite

Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress immune responses. Thus, the research and development of novel anticancer peptides with low toxicity to normal human cells and mechanisms of action capable of avoiding multi-drug resistance may provide a new method for anticancer treatment. This review provides useful information on the potential of marine anticancer peptides for human therapy.

show abstract

“…[5][6][7] Mollamides are anticancer lead cyanobactins that were isolated in milligrams from ten kilograms of ascidians. [8] As a chemically unrelated example, patellazoles are very potent anticancer polyketides from ascidians, but they cannot be developed because they are rarely found, even in the same location from year-toyear. [9][10][11] This variability promises an almost unlimited source of new bioactive marine natural products.…”

Section: Introductionmentioning

confidence: 99%

Accessing the Hidden Majority of Marine Natural Products through Metagenomics

et al. 2011

View full text Add to dashboard Cite

Tiny marine animals represent an untapped reservoir for undiscovered, bioactive natural products. However, their small size and extreme chemical variability preclude traditional chemical approaches to discovering new bioactive compounds. Here, we use a metagenomic method to directly discover and rapidly access cyanobactin class natural products from these variable samples, providing proof-of-concept for genome based discovery and supply of marine natural products. We also address practical optimization of complex, multistep ribosomal peptide pathways in heterologous hosts, which is still very challenging. The resulting methods and concepts will be applicable to ribosomal peptide and other biosynthetic pathways.

show abstract

Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate Didemnum molle

Cited by 87 publications

References 22 publications

Marine Peptides and Their Anti-Infective Activities

Marine Peptides and Their Anti-Infective Activities

Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides

Accessing the Hidden Majority of Marine Natural Products through Metagenomics

Contact Info

Product

Resources

About