Molecule-specific vibration-based chiral differentiation of Raman spectra using cysteine modified gold nanoparticles: the cases of tyrosine and phenylalanine

Sun, Xueping; Wang, Ning; He, Yanxiu; Kong, Huanjun; Yang, Haifeng; Liu, Xinling

doi:10.1039/d1tb00983d

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…During the present study, amino acid capping was performed differently in the living body. Chirality-dependent properties of amino acids also influenced biochemical pathways in different ways [ 13 ]. Nanomaterials (NMs) also influenced the regulation of MTs in tissues.…”

Section: Discussionmentioning

confidence: 99%

Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential

et al. 2023

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Biomolecules-based surface modifications of nanomaterials may yield effective and biocompatible nanoconjugates. This study was designed to evaluate gold nanoconjugates (AuNCs) for their altered antioxidant potential. Gold nanoparticles (AuNPs) and their conjugates gave SPR peaks in the ranges of 512–525 nm, with red or blueshift for different conjugates. Cys-AuNCs demonstrated enhanced ( p < 0.05) and Gly-AuNCs ( p > 0.05) displayed reduced DPPH activity. Gly-AuNCs and Tyr-AuNCs displayed enhanced ferric-reducing power and hydrogen peroxide scavenging activity, respectively. Cadmium-intoxicated mice were exposed to gold nanomaterials, and the level of various endogenous parameters, i.e., CAT, GST, SOD, GSH, and MTs, was evaluated. GSH and MTs in liver tissues of the cadmium-exposed group (G2) were elevated ( p < 0.05), while other groups showed nonsignificance deviations than the control group. It is concluded that these nanoconjugates might provide effective nanomaterials for biomedical applications. However, more detailed studies for their safety profiling are needed before their practical applications.

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Section: Discussionmentioning

confidence: 99%

Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential

et al. 2023

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“…Sun et al used Cys-modified gold NPs to identify tyrosine (Tyr) or Phe enantiomers. When the chiral configuration of Tyr or Phe was identical to that of Cys, the obtained Raman scattering signals were several times stronger than those with the opposite chirality, 70 allowing for widespread application of chirality-related detection with high specificity and sensitivity. It was observed that β-cyclodextrin-modified silver NPs aggregated in the presence of l -Tyr due to the preferential recognition with l -Tyr, 71 which resulted in the signal simplification of pulse voltammograms and can be used for chiral discrimination of tyrosine enantiomers.…”

Section: Biological Applicationsmentioning

confidence: 99%

Chiral inorganic nanomaterials for biological applications

et al. 2023

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“…Its circular dichroism is greater than phe. [172][173][174] In 2016, Gao et al briefly mentioned the concept of Cys self-assembly on the surface of Au or Ag via mercaptan group (SH) to obtain enantioselective GOxlike activity. [104] The results demonstrated that the presence of a chiral catalyst in a mixture of 0.2 times fructose, glycine, BSA and K + , Ca 2+ , Co 2+ , Zn 2+ , Pb 2+ , UA, AA, PA did not affect glucose detection.…”

Section: Amino Acid-functionalized Nmnzsmentioning

confidence: 99%

Detection of Glucose Based on Noble Metal Nanozymes: Mechanism, Activity Regulation, and Enantioselective Recognition

Chen

Liu

Zheng

et al. 2022

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Glucose monitoring is essential to evaluate the degree of glucose metabolism disorders. The enzymatic determination has been the most widely used method in glucose detection because of its high efficiency, accuracy, and sensitivity. Noble metal nanomaterials (NMs, i.e., Au, Ag, Pt, and Pd), inheriting their excellent electronic, optical, and enzyme‐like properties, are classified as noble metal nanozymes (NMNZs). As the NMNZs are often involved in two series of reactions, the oxidation of glucose and the chromogenic reaction of peroxide, here the chemical mechanism by employing NMNZs with glucose oxidase (GOx) and peroxidase (POD) mimicking activities is briefly summarized first. Subsequently, the regulation strategies of the GOx‐like, POD‐like and tandem enzyme‐like activities of NMNZs are presented in detail, including the materials, size, morphology, composition, and the reaction condition of the representative NMs. In addition, in order to further mimic the enantioselectivity of enzyme, the design of NMNZs with enantioselective recognition of d‐glucose and l‐glucose by using different chiral compounds (DNA, amino acids, and cyclodextrins) and molecular imprinting is further described in this review. Finally, the feasible solutions to the existing challenges and a vision for future development possibilities are discussed.

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Molecule-specific vibration-based chiral differentiation of Raman spectra using cysteine modified gold nanoparticles: the cases of tyrosine and phenylalanine

Abstract: The chirality of amino acids plays a key role in many biochemical processes, and the development of spectroscopic analysis methods for chiral differentiation of amino acids is significant. Normal Raman...

Cited by 14 publications

References 24 publications

Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential

Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential

Chiral inorganic nanomaterials for biological applications

Detection of Glucose Based on Noble Metal Nanozymes: Mechanism, Activity Regulation, and Enantioselective Recognition

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