Molecularly imprinted solid phase extraction method for simultaneous determination of seven nitroimidazoles from honey by HPLC-MS/MS

Guo, Xiuchun; Xia, Zhaoyang; Wang, Hai-Hui; Kang, Wenyi; Liming, Lin; Cao, Wenqing; Zhang, Hongwei; Zhou, Wenhui

doi:10.1016/j.talanta.2017.01.047

Cited by 44 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most notable feature of molecular imprinting technology is its specic recognition, which can identify and enrich target molecules from complex matrices; this approach is oen used to selectively enrich materials that are used as samples and for the preparation of molecularly imprinted polymers. [5][6][7] However, traditional molecularly imprinted polymers have a large internal core mass transfer resistance, and the active site is embedded too deeply, which makes it difficult to elute the template molecules and results in poor reusability. To solve this problem, the surface imprinting method initiates the polymerization reaction on the surface of the carrier so that the binding site is located on the surface.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A consolidated application of MIT combines the advantages of molecular recognition of molecularly imprinted polymers (MIPs) with a traditional SPE technique. In this way, molecularly imprinted solid‐phase extraction (MISPE) presents a high specificity, selectivity, and sensitivity of the molecular recognition mechanism and a high resolving power of separation methods for selective extraction and quantification of biological l ‐Kyn from human urine samples . To date, up to our knowledge, no other works have been made in the field of MIPs using l ‐Kyn as a template.…”

Section: Introductionmentioning

confidence: 99%

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

Mergola

Orabona

Albini

et al. 2018

J of Separation Science

View full text Add to dashboard Cite

l-Kynurenine is an endogenous metabolite generated by the catabolic pathway of l-tryptophan and it could be a potential biomarker to test the efficacy of several checkpoint inhibitors that have already reached the clinical trials in the antitumor therapy. Thus, a molecularly imprinted polymer specific for the recognition of this metabolite was synthesized and used as innovative system in solid-phase extraction technique for the specific extraction and quantification of l-kynurenine in human urine. The off-line system was firstly tested on l-kynurenine standard solutions, allowing recoveries up to 97.7% (relative standard deviation = 2.2%) and then applied to fortified and deproteinated human urine samples, where a recovery of 84.1% (relative standard deviation = 3.1%) was obtained. The method was validated and it revealed a good linearity in the range of 0.157-20 μg/mL (r = 0.9992). The optimized procedure demonstrated a good feasibility on biological samples, allowing a ready quantification of l-kynurenine in the human urine, where the metabolite was found at a very low concentration (0.80 μg/mL). The extraction system developed could attract attention of pharmaceutical industries for l-kynurenine production as potential drug in the treatment of autoimmune disorders through its extraction and purification from biological matrixes.

show abstract

“…Almost all MIP adsorbents for food samples were synthesized via non‐covalent imprinting techniques. Moreover, the bulk polymerization is one of the frequently used polymerization methods for preparing MIP particles [23,25,28,83–87]. Garcia et al.…”

Section: Applications Of Molecularly Imprinted Polymer‐based Spe To Rmentioning

confidence: 99%

Recent advances and applications of molecularly imprinted polymers in solid‐phase extraction for real sample analysis

Chen

Wang

et al. 2021

J of Separation Science

View full text Add to dashboard Cite

Sample pretreatment is essential for the analysis of complicated real samples due to their complex matrices and low analyte concentrations. Among all sample pretreatment methods, solid‐phase extraction is arguably the most frequently used one. However, the majority of available solid‐phase extraction adsorbents suffer from limited selectivity. Molecularly imprinted polymers are a type of tailor‐made artificial antibodies and receptors with specific recognition sites for target molecules. Using molecularly imprinted polymers instead of conventional adsorbents can greatly improve the selectivity of solid‐phase extraction, and therefore molecularly imprinted polymer‐based solid‐phase extraction has been widely applied to separation, clean up and/or preconcentration of target analytes in various kinds of real samples. In this article, after a brief introduction, the recent developments and applications of molecularly imprinted polymer‐based solid‐phase extraction for determination of different analytes in complicated real samples during the 2015‐2020 are reviewed systematically, including the solid‐phase extraction modes, molecularly imprinted adsorbent types and their preparations, and the practical applications of solid‐phase extraction to various real samples (environmental, food, biological, and pharmaceutical samples). Finally, the challenges and opportunities of using molecularly imprinted polymer‐based solid‐phase extraction for real sample analysis are discussed.

show abstract

Molecularly imprinted solid phase extraction method for simultaneous determination of seven nitroimidazoles from honey by HPLC-MS/MS

Cited by 44 publications

References 25 publications

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

Urinary l‐kynurenine quantification and selective extraction through a molecularly imprinted solid‐phase extraction device

Recent advances and applications of molecularly imprinted polymers in solid‐phase extraction for real sample analysis

Contact Info

Product

Resources

About