Molecularly imprinted polymers prepared in aqueous solution selective for [Sar1,Ala8]angiotensin II

Rachkov, A. E.; Hu, Minjie; Bulgarevich, Elena; Matsumoto, Tadashi; Minoura, Norihiko

doi:10.1016/s0003-2670(03)00764-5

Cited by 61 publications

(33 citation statements)

References 30 publications

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“…By forming numerous interaction points they attempt to obtain specificity through steric properties as well as complementary chemistries. An alternative to this entitled the "epitope" approach has been developed by Rachkov, where the template used for polymer development is not the whole protein but a short peptide that represents part of a larger polypeptide or protein, as an epitope represents an antigen in immunology (Figure 4) (57)(58)(59). This is technically not imprinting of proteins in the traditional sense but is included as the ultimate goal is to obtain recognition of the parent molecule.…”

Section: Dmentioning

confidence: 99%

From 3D to 2D: A Review of the Molecular Imprinting of Proteins

Turner¹,

Jeans²,

Brain³

et al. 2006

Biotechnol. Prog.

186

217

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Molecular imprinting is a generic technology that allows for the introduction of sites of specific molecular affinity into otherwise homogeneous polymeric matrices. Commonly this technique has been shown to be effective when targeting small molecules of molecular weight <1500, while extending the technique to larger molecules such as proteins has proven difficult. A number of key inherent problems in protein imprinting have been identified, including permanent entrapment, poor mass transfer, denaturation, and heterogeneity in binding pocket affinity, which have been addressed using a variety of approaches. This review focuses on protein imprinting in its various forms, ranging from conventional bulk techniques to novel thin film and monolayer surface imprinting approaches.

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Section: Dmentioning

confidence: 99%

From 3D to 2D: A Review of the Molecular Imprinting of Proteins

Turner¹,

Jeans²,

Brain³

et al. 2006

Biotechnol. Prog.

186

217

View full text Add to dashboard Cite

show abstract

“…Many attempts have been made to optimize the imprinting parameters in order to obtain MIPs with water compatibility [21][22][23][24][25][26]. These include careful selection of appropriate type and ratio of monomers, cross-linkers and porogens [27].…”

Section: Syntheses Of Nam Imprinted Polymers and Their Binding Efficimentioning

confidence: 99%

Synthesis of nicotinamide-imprinted polymers and their binding performances in organic and aqueous media

et al. 2008

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Abstract:To obtain molecularly imprinted polymers capable of selective rebinding with nicotinamide (NAM), NAM imprinted polymers were synthesized via bulk polymerization using various functional monomers and cross-linkers. The NAM recognition properties of these polymers were investigated in organic and aqueous solvents by equilibrium rebinding experiments. The results show that the imprinted polymer prepared using 1:4:4 molar ratio of NAM/MAA/TRIM in dichloromethane exhibited the greatest NAM binding capacity and selectivity. This polymer is potentially valuable for the analysis of NAM in complex matrices where selective isolation and identification are needed.

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“…Hemoglobin, cytochrome c, and transferrin have been used as templates [29][30][31]. The imprinted gels were granulated by passage through 100-mesh sieves and packed into columns in Pasteur pipettes; these had selective binding capacity for the template proteins.…”

Section: Rational Design Of Protein-imprinted Materialsmentioning

confidence: 99%

“…Rachkov et al first developed an epitope imprinting approach similar to those applied for small-molecule imprinting [18,[30][31][32]. In Rachkov's initial research, a tetrapeptide, YPLG, was imprinted on the conventional polymer matrix with MAA as monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinker [30].…”

Section: Rational Design Of Protein-imprinted Materialsmentioning

confidence: 99%