Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

Abstract

Environmental contaminants constitute an ecological and health hazard, which requires green sensing. The RAFT-MIP approach for tailor-made selective receptors enhances them via binding affinities for use in environmental contaminant sensors.

Molecularly Imprinted Plasmonic Sensors as Nano-Transducers: An Effective Approach for Environmental Monitoring Applications

“…These techniques were influenced by the type of interactions observed between the functional monomer and the template molecules or target analytes [27]. Interestingly, Mosbach and coworkers focused their research on employing the non-covalent technique for polymer-based imprinting, while Wulff and his research group used the covalent approach in creating the imprints [30]. The main difference between these two techniques is related to the removal or detachment of the template molecules from the polymer framework [27,30].…”

“…Interestingly, Mosbach and coworkers focused their research on employing the non-covalent technique for polymer-based imprinting, while Wulff and his research group used the covalent approach in creating the imprints [30]. The main difference between these two techniques is related to the removal or detachment of the template molecules from the polymer framework [27,30]. The template removal plays an integral part of the binding affinity for targets, hence it was confirmed that the covalent technique produced more uniformly distributed binding sites while the non-covalent technique yielded non-homogenous binding sites [27].…”

“…MIPs are synthetic antibodies with a robust polymeric platform that is highly sensitive and specific in detecting a myriad of environmental targets in various matrices [15]. The development of MIPs as synthetic antibodies has been an idealistic concept; however, thirty (30) years later, it is still a challenge to reproduce MIPs accurately as three-dimensional complexes of either DNA or protein moieties [16]. Although MIPs have limitations such as mimicking the exact functionality of enzymes and antibodies, they have proven to be a better alternative to biological receptors regarding their robust sensing capability and a host of superior characteristics.…”

Fabrication of a Molecularly-Imprinted-Polymer-Based Graphene Oxide Nanocomposite for Electrochemical Sensing of New Psychoactive Substances

“…Compared with other living/control radical polymerization techniques, RAFT polymerization not only allowed the synthetic tailoring of polymers with narrow molecular weight distribution, controlled molecular weight, and diverse terminal functionality, but has also been performed under mild reaction conditions with a wide range of monomers. Therefore, the specially-designed polymer structure can been used to improve the features of molecular imprinting such as maximum adsorption capacity, selectivity, and sensitivity [ 32 ].…”

Pre-polymerization process simulation, synthesis and investigation the properties of dipicolinic acid molecularly imprinted polymers

“…Important parameters such as solvent polarity, reaction temperature, and stirring speed significantly influence the size and morphology of MIPs particles in this method [ 9 ]. RAFT is a slow, thermodynamically controlled technique that allows polymer chain growth and produces homogeneous polymers [ 10 ]. In the sol–gel method, solid nanoparticles dispersed in a liquid (a sol) aggregate together to form a continuous three-dimensional network that extends throughout the liquid (gel).…”