Molecularly Imprinted Polymers for Cell Recognition

Abstract

Since their conception fifty years ago, molecularly imprinted polymers (MIPs) have seen extensive development both in terms of synthetic routes and applications. Perhaps the most challenging target for molecular imprinting are cells. Though early work was based almost entirely around microprinting methods, recent developments shifted towards epitope imprinting to generate MIP nanoparticles. Simultaneously, the development of techniques such as solid phase MIP synthesis have solved many historic issues of MIP production. This review briefly describes various approached used in cell imprinting with a focus on applications of the created materials in imaging, drug delivery, diagnostics and tissue engineering.

Interaction of LiYF4:Yb3+/Er3+/Ho3+/Tm3+@LiYF4:Yb3+ upconversion nanoparticles, molecularly imprinted polymers, and templates

“…Aer coating the LiYF 4 :Yb 3+ /Er 3+ /Tm 3+ /Ho 3+ cores with the LiYF 4 :Yb 3+ shell, the short axis lengths of the tetragonal crystals for the core/shell nanoparticles increased signicantly to 44. 3 core/shell nanoparticles that match well with the distance between the (202) planes in the LiYF 4 of the single-crystalline structure (Fig. 2C).…”

“…Molecular imprinting is a powerful method for the preparation of polymeric materials with tailor-made molecular recognition binding sites that have been used in applications such as chemical separations, catalysis, or molecular sensors. [1][2][3] The in situ polymerization of molecularly imprinted polymers (MIPs) is based on the copolymerization of the template and functional monomers through covalent/non-covalent interactions with crosslinkers. 4,5 Aer polymerization, these materials retain special cavities with corresponding steric and chemical memories upon the removal of the template.…”

Molecular Imprinted Polymers Coupled to Photonic Structures in Biosensors: The State of Art

“…The process of template removal, usually performed by means of washings, leaves binding cavities on the MIP that have affinity and selectivity for their target template and can be used for its selective capture. Adapted from [ 9 ].…”

“…MIPs are polymeric synthetic receptors prepared by means of a template assisted synthesis. The use of MIPs in optical sensing offers a number of advantages, such as the possibility to prepare an MIP-MRE suitable to capture any kind of target analyte, from small molecules to proteins [ 8 ], cells and viruses [ 9 ]. MIPs can be addressed at the recognition of immunogenic and toxic analytes, and can be entailed to the desired degree of affinity and selectivity [ 10 , 11 ], so that some of the MIP materials demonstrated to outpass the characteristics of their natural counterparts, such as antibodies or biological receptors.…”

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

“…In this review, current trends in the development of MIPs/SIPs based electrochemical biosensors for rapid assessment of the infectious diseases, as well as future research directions are comprehensively summarized and discussed. Virus-imprinted polymers (VIPs) [12] for virus detection and cell-imprinted polymers (CIPs) [13] for bacteria detection are highlighted ( Figure 1).…”