Molecularly-imprinted polymer sensors: realising their potential

Uzun, Lokman; Turner, Anthony P. F.

doi:10.1016/j.bios.2015.07.013

Cited by 420 publications

(188 citation statements)

References 78 publications

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“…[509][510][511][512] The characteristic feature of MIP-based sensors is that the MIPs have both recognition and transduction properties, that is, the MIPs as recognition elements can specifically bind target analytes and as transduction elements can generate output signals for detection. The characteristic feature and basic construction of MIP-based sensors are schematically illustrated in Fig.…”

Section: Chemical and Biological Sensingmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: Chemical and Biological Sensingmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Due to their molecular recognition capability, MIPs have captured the imagination of many and their use is encouraged in numerous application areas such as in: solid-phase extraction (Tamayo et al, 2007;Lanza & Sellergren, 2001;Andersson & Schweitz, 2003); sensor (Liu et al, 2012;Uzun & Turner, 2016;Haupt & Mosbach, 2006); chromatography (Yan et al, 2007); amino acid derivatives (Scorrano et al, 2011); and drugs (Sellergren & Allender, 2005;Lulinski, 2013). Not only easy and low-cost, the synthesis of MIPs also produced polymers that are stable, versatile and resistant to a wide range of pH, solvents and temperature (Cormack & Elorza, 2004).…”

Section: Introductionmentioning

confidence: 99%

Isotherm Studies of Pyrogallol-imprinted Polymers via Precipitation Polymerization

Othman

Yusof

Daik³

et al. 2017

IJTech

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Molecularly imprinted polymers (MIPs) have been the most convenient and selected methods in detection and extraction for many types of specific targets in various fields. MIPs were prepared by mixing template molecule with functional monomer in the presence of cross-linker, solvent and initiator. The selectivity of MIPs is strongly influenced by the types of functional monomer, solvent and polymerization process used. Pyrogallol-imprinted polymer (Py-IP) and nonimprinted polymer (NIP) were synthesized via precipitation polymerization using 4-vinylpyridine (4-VP), divinylbenzene (DVB) and azobisisobutyronitrile (AIBN) as functional monomer, cross-linker and initiator, respectively. Pyrogallol (Py) was used as a target molecule. The synthesized polymers were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and UV-Visible Spectroscopy (UV-Vis). In this study, adsorption capacity was measured by the dosage effect, contact time and selectivity study. Results showed that maximum adsorption capacity by Py-IP is above 50%. The Selectivity study shows that k' is >1, which indicates that Py-IP has a good selectivity towards pyrogallol. Therefore, it has a good potential to be used as an adsorbent.

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“…Since then, the technique of self-polymerization has been employed in several studies for the imprinting of proteins on various platforms such as magnetic [51,52], gold [53], or silica nanoparticles [54,55], silicon nanowires [56], 4-vinylphenylboronic acid-based monolithic skeletons [57], gold electrodes [58,59], or multi-walled carbon nanotubes [60]. These studies showed that apart from the advantage of controllable thickness, MIPs comprised of polydopamine exhibit good to excellent binding properties, have high hydrophilicity, biocompatibility, as well as pH (3)(4)(5)(6)(7)(8)(9)(10)(11) and longtime stability [61].…”

Section: Electropolymerizationmentioning

confidence: 99%

“…Chemosensors 2017, 5, 11 2 of 16 than 1200 papers on MIPs are published per year [5][6][7][8][9]. Some ten percent of MIP papers describe artificial receptors for proteins [7,[10][11][12][13], including enzymes [13][14][15][16][17][18][19][20][21].…”

Section: Preparation Of Surface Imprinted Mipsmentioning

confidence: 99%

Enzymes as Tools in MIP-Sensors

et al. 2017

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Abstract:Molecularly imprinted polymers (MIPs) have the potential to complement antibodies in bioanalysis, are more stable under harsh conditions, and are potentially cheaper to produce. However, the affinity and especially the selectivity of MIPs are in general lower than those of their biological pendants. Enzymes are useful tools for the preparation of MIPs for both low and high-molecular weight targets: As a green alternative to the well-established methods of chemical polymerization, enzyme-initiated polymerization has been introduced and the removal of protein templates by proteases has been successfully applied. Furthermore, MIPs have been coupled with enzymes in order to enhance the analytical performance of biomimetic sensors: Enzymes have been used in MIP-sensors as "tracers" for the generation and amplification of the measuring signal. In addition, enzymatic pretreatment of an analyte can extend the analyte spectrum and eliminate interferences.

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Molecularly-imprinted polymer sensors: realising their potential

Cited by 420 publications

References 78 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Isotherm Studies of Pyrogallol-imprinted Polymers via Precipitation Polymerization

Enzymes as Tools in MIP-Sensors

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