Molecularly imprinted polymer based micromechanical cantilever sensor system for the selective determination of ciprofloxacin

Okan, Meltem; Sarı, Esma; Duman, Memed

doi:10.1016/j.bios.2016.08.047

Cited by 51 publications

(30 citation statements)

References 22 publications

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“…[5][6][7] Its means of detection are based on two AFM techniques: (1) spectroscopy of AFM tips through force curve measurements, 8 and (2) measurement of cantilever de°ection, which analyzes surface stress due to the chemical bindings or reactions occurring on immobilized surfaces. 5,9 Other approaches to de°ection analysis can be accomplished by changing the resonance frequency of the cantilever to the dynamic mode. 5,9 Both devices (tip or cantilever) can be used in either the liquid or gaseous environment to detect proteins, 5,10,11 DNA, 12,13 RNA, 14 or even pesticides, 8 in real-time and with high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…5,9 Other approaches to de°ection analysis can be accomplished by changing the resonance frequency of the cantilever to the dynamic mode. 5,9 Both devices (tip or cantilever) can be used in either the liquid or gaseous environment to detect proteins, 5,10,11 DNA, 12,13 RNA, 14 or even pesticides, 8 in real-time and with high sensitivity. Nanomechanical sensors based on cantilever devices can be applied to target molecules for medical purposes, 5 such as in the detection of neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

“…15 Operational procedures can be carried out in a dynamic or static mode, depending on measurement properties; parameters such as resonance or de°ection will apply to the use of either the dynamic mode or the static mode, respectively. 9,16 In static mode, detection is performed by recording cantilever de°ections; these depend on the arrangement of biomolecules on the cantilever's surface. 1,9 In dynamic mode, detection is performed through monitoring changes in resonance frequency that occur as a result of the overall adsorption of the bulk substance on the cantilever surface.…”

Section: Introductionmentioning

confidence: 99%

“…9,16 In static mode, detection is performed by recording cantilever de°ections; these depend on the arrangement of biomolecules on the cantilever's surface. 1,9 In dynamic mode, detection is performed through monitoring changes in resonance frequency that occur as a result of the overall adsorption of the bulk substance on the cantilever surface. 1,9,17 To act as a high-precision sensor, the cantilever must be covered (functionalized) with a monolayer of a molecular functional group that is speci¯c to, and capable of recognizing, a previously selected target molecule.…”

Section: Introductionmentioning

confidence: 99%

“…1,9 In dynamic mode, detection is performed through monitoring changes in resonance frequency that occur as a result of the overall adsorption of the bulk substance on the cantilever surface. 1,9,17 To act as a high-precision sensor, the cantilever must be covered (functionalized) with a monolayer of a molecular functional group that is speci¯c to, and capable of recognizing, a previously selected target molecule. 18,19 Functionalization involves a chemical linkage process that adheres the molecular functional groups to the cantilever surface in a layer-by-layer fashion, where functional groups interact with their respective biological target material, resulting in immobilization.…”

Section: Introductionmentioning

confidence: 99%

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Nanomechanical Cantilever-Based Sensor: An Efficient Tool to Measure the Binding Between the Herbicide Mesotrione and 4-Hydroxyphenylpyruvate Dioxygenase

Rodrigues

Ierich

Andrade

et al. 2017

NANO

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Nanomechanical biosensors based on atomic force microscopy (AFM) cantilevers have garnered considerable attention. AFM cantilevers are devices that can detect a target either via a surface functionalization process based on immobilization through molecular adsorption, or through the selective chemical binding of a speci¯c molecule, transforming the device into a speci¯c biosensor. In this study, we demonstrate that functionalized AFM cantilevers could be used, in a process involving self-assembling layers, to create a homogeneous surface layer of the widely used herbicide mesotrione. Controlled experiments to evaluate its detection were performed, and binding between mesotrione and its target molecule, 4-hydroxyphenylpyruvate dioxygenase (HPPD), was evaluated using de°ection curves of functionalized cantilevers interacting with mesotrione. The cantilevers worked as nanomechanical sensors inside a°uid cell device, under di®erent ¶ Corresponding author. 1750079-1NANO: Brief Reports and Reviews Vol. 12, No. 7 (2017) concentrations of HPPD diluted in PBS. After evaluating increasing concentrations of HPPD, the de°ection curves showed a clear, dose-dependent pattern. The homogeneous dispersion of mesotrione on the cantilevers was assessed by confocal microscopy, and this corroborated the functionalization method. Thus, the results obtained by this functionalized cantilever presented a high e±ciency in detecting binding between HPPD and mesotrione molecules at concentrations as low as 17 ng mL À1 . In this way, as a preliminary step for a future environmental contaminants nanosensor development, the described detection method showed a suitable capability for molecular recognition at the nanoscale.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nanomechanical Cantilever-Based Sensor: An Efficient Tool to Measure the Binding Between the Herbicide Mesotrione and 4-Hydroxyphenylpyruvate Dioxygenase

Rodrigues

Ierich

Andrade

et al. 2017

NANO

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Development of a New Voltammetric Methodology for the Determination of Ciprofloxacin in Beef Samples Using a Carbon Paste Electrode Modified with Nafion and Fullerenes

et al. 2021

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A sensitive, selective, and low cost electrochemical new methodology was developed for the quantification of ciprofloxacin (Cip) in beef samples by cyclic voltammetry and differential pulse voltammetry, using a CPE electrode modified with Nafion and Fullerenes (N−F/CPE). The optimum parameters for the composition of the N−F/CPE electrode are 0.19 g mineral oil, 0.01 g Nafion, 50 μL fullerene, and graphite powder 0.3 g. The electrochemical characterization was carried out by obtaining maximum anodic peak current associated with the oxidation of ciprofloxacin at 1.1 V, where the electrochemical process resulted to be irreversible and diffusion‐controlled. The analytical characterization of the proposed methodology was carried out resulting in a LOD of 1.0 μmol L−1, a LOQ of 3.0 μmol L−1, a sensitivity of 0.37±0.006 μA/μmolL−1, and repeatability of 5.38 %.

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Ultrasensitive monitoring of Ciprofloxacin with green reduced graphene oxide@clay composite

Azriouil,

Hrioua,

Chhaibi

et al. 2024

Electroanalysis

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Molecularly imprinted polymer based micromechanical cantilever sensor system for the selective determination of ciprofloxacin

Cited by 51 publications

References 22 publications

Nanomechanical Cantilever-Based Sensor: An Efficient Tool to Measure the Binding Between the Herbicide Mesotrione and 4-Hydroxyphenylpyruvate Dioxygenase

Nanomechanical Cantilever-Based Sensor: An Efficient Tool to Measure the Binding Between the Herbicide Mesotrione and 4-Hydroxyphenylpyruvate Dioxygenase

Development of a New Voltammetric Methodology for the Determination of Ciprofloxacin in Beef Samples Using a Carbon Paste Electrode Modified with Nafion and Fullerenes

Ultrasensitive monitoring of Ciprofloxacin with green reduced graphene oxide@clay composite

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