Molecularly Imprinted Polymer-Based Biosensors: For the Early, Rapid Detection of Pathogens, Biomarkers, and Toxins in Clinical, Environmental, or Food Samples

Lin, Zuan-Tao; DeMarr, Victoria; Bao, Jiming; Wu, Tianfu

doi:10.1109/mnano.2017.2779718

Cited by 18 publications

(22 citation statements)

References 31 publications

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“…Therefore, such artificially created cavities are very selectively recognizing imprinted molecules and the action of MIPs is similar to that of antibodies or receptors. In addition, MIPs-based sensors are rather stable, because they mostly are based on a stable polymeric-matrix, e.g., acrylamide [ 171 ], acrylic acid and methacrylic acid, which both are frequently applied in the design of various molecularly imprinted polymer-based structures [ 172 , 173 , 174 , 175 ]. For the development of MIPs many different methods can be applied.…”

Section: Formation Of Mips Imprinted By Proteins and By Other Largmentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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Recent challenges in biomedical diagnostics show that the development of rapid affinity sensors is very important issue. Therefore, in this review we are aiming to outline the most important directions of affinity sensors where polymer-based semiconducting materials are applied. Progress in formation and development of such materials is overviewed and discussed. Some applicability aspects of conducting polymers in the design of affinity sensors are presented. The main attention is focused on bioanalytical application of conducting polymers such as polypyrrole, polyaniline, polythiophene and poly(3,4-ethylenedioxythiophene) ortho-phenylenediamine. In addition, some other polymers and inorganic materials that are suitable for molecular imprinting technology are also overviewed. Polymerization techniques, which are the most suitable for the development of composite structures suitable for affinity sensors are presented. Analytical signal transduction methods applied in affinity sensors based on polymer-based semiconducting materials are discussed. In this review the most attention is focused on the development and application of molecularly imprinted polymer-based structures, which can replace antibodies, receptors, and many others expensive affinity reagents. The applicability of electrochromic polymers in affinity sensor design is envisaged. Sufficient biocompatibility of some conducting polymers enables to apply them as “stealth coatings” in the future implantable affinity-sensors. Some new perspectives and trends in analytical application of polymer-based semiconducting materials are highlighted.

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Section: Formation Of Mips Imprinted By Proteins and By Other Largmentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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“…Hence, MIPs mimic the action of receptors and antibodies. Polymers such as methacrylic acid, acrylamide, and acrylic acid are often used to design MIP-based sensors; such sensors are mostly suitable for the determination of low molecular weight analytes [ 101 , 102 , 103 , 104 ]. MIP based on methacrylic acid was applied in the design of sensors for the determination of six different steroids, namely, testosterone, Δ4-androstene-3,17-dione, 1,4-androstadiene-3,17-dione, β-estradiol, progesterone, and testosterone propionate [ 103 ], and a bifunctional monomer, N-phenylethylene diamine methacrylamide, was used for the construction of the electrochemical sensor for the detection of β-estradiol [ 104 ].…”

Section: Molecularly Imprinted Polymers (Mips) Based Sensorsmentioning

confidence: 99%

“…In some MIP formation strategies, functional groups can be attached to polymeric backbone in order to form a complex between the MIP and analyte [ 104 ]. Initially imprinted analyte molecules are removed by washing them out from the formed MIP-matrix [ 102 ]. In comparison with antibodies or receptors, MIPs have significantly better stability at room temperatures.…”

Section: Molecularly Imprinted Polymers (Mips) Based Sensorsmentioning

confidence: 99%

“…In comparison with antibodies or receptors, MIPs have significantly better stability at room temperatures. According to monomers applied in the design of MIPs, there are three general types of such structures: (i) the most simple MIPs are based on one type of monomer, which form CPs [ 102 ]; (ii) other types of sensors are based on copolymers, which contain one type of monomer creating a polymer matrix and one or more types of monomers forming a complex with analyte [ 106 ]; and (iii) sensors based on ‘overoxidizable’ CPs, which possess functional groups created by electrochemical or chemical overoxidation of polymer, after the entrapment of analyte [ 110 , 118 ].…”

Section: Molecularly Imprinted Polymers (Mips) Based Sensorsmentioning

confidence: 99%

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Conducting Polymers in the Design of Biosensors and Biofuel Cells

2020

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Fast and sensitive determination of biologically active compounds is very important in biomedical diagnostics, the food and beverage industry, and environmental analysis. In this review, the most promising directions in analytical application of conducting polymers (CPs) are outlined. Up to now polyaniline, polypyrrole, polythiophene, and poly(3,4-ethylenedioxythiophene) are the most frequently used CPs in the design of sensors and biosensors; therefore, in this review, main attention is paid to these conducting polymers. The most popular polymerization methods applied for the formation of conducting polymer layers are discussed. The applicability of polypyrrole-based functional layers in the design of electrochemical biosensors and biofuel cells is highlighted. Some signal transduction mechanisms in CP-based sensors and biosensors are discussed. Biocompatibility-related aspects of some conducting polymers are overviewed and some insights into the application of CP-based coatings for the design of implantable sensors and biofuel cells are addressed. New trends and perspectives in the development of sensors based on CPs and their composites with other materials are discussed.

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“…Before diving into the reasons behind this dramatic change of the trends, several aspects concerning the use of MIPs as recognition elements in the development of sensors should be summarized. Compared to biological recognition elements, MIPs [34,35,36,37,38,39,40]: (1) are more stable under different chemical, thermal and mechanical conditions; (2) show high performance in the presence of aqueous/organic mixtures or even pure organic solvents; (3) can be considered as “low-cost” materials, as do not require animal experimentation, the template can be recovered and further purified after the synthesis if needed and those cases where extremely toxic and/or expensive reagents are required, templates can be substituted by cheaper and non-harmful analogues; (4) can be prepared even for those compounds for which there are no biological recognition elements available. On the other hand, they: (1) show slower binding kinetics; (2) cannot respond upon binding of non-active optical analytes; (3) should be integrated and coupled to the transducer element, which sometimes is complicated due to the polymeric nature of the material; (4) are limited to the detection of only one analyte hindering simultaneous detection.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Rico-Yuste¹,

Carrasco

2019

Polymers

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We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

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Molecularly Imprinted Polymer-Based Biosensors: For the Early, Rapid Detection of Pathogens, Biomarkers, and Toxins in Clinical, Environmental, or Food Samples

Cited by 18 publications

References 31 publications

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Conducting Polymers in the Design of Biosensors and Biofuel Cells

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

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