Molecular Understanding of Osteoclast Differentiation and Physiology

Lee, Na Kyung

doi:10.3803/enm.2010.25.4.264

Cited by 17 publications

(11 citation statements)

References 64 publications

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“…A possible reason could be its functional involvement in the migration of osteoclast precursors from peripheral blood to the bone surface [26,27]. It is known that CSF1 through its receptor c-fms induces proliferation and survival of osteoclasts, whereas ACP5 is a wellknown osteoclast specific marker [28]. Our results of DEGs, TFs, PPIs, gene ontology and previous findings (29)(30)(31)(32)(33)(34) suggest that hematopoietic cells in presence of transcription factor PU.1 form Myeloid/ Monocyte lineage cells like osteoclast precursors [29,30].…”

Section: Discussionsupporting

confidence: 69%

Differential Gene Expression Pattern in Osteoclast Precursor Cells of Indian Postmenopausal Women with and Without Osteoporosis: A Microarray Based Study

Raje¹,

Mhaske²,

Ghosh³

et al. 2017

J Bone Res

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Section: Discussionsupporting

confidence: 69%

Differential Gene Expression Pattern in Osteoclast Precursor Cells of Indian Postmenopausal Women with and Without Osteoporosis: A Microarray Based Study

Raje¹,

Mhaske²,

Ghosh³

et al. 2017

J Bone Res

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“…Carbonic anhydrase II (CAII) is the major cytoplasmic source of protons needed for acidification of the lacuna at gradient pH. This enzyme converts carbon dioxide (CO 2 ) to carbonic acid (H 2 CO 3 ), which subsequently undergoes ionization to form carbonate and hydrogen ions [6,10,11,12]. A proton pump, ATPase transfers the protons produced by CAII into intracellular vesicles.…”

Section: Mechanism Of Bone Resorption Processmentioning

confidence: 99%

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Agidigbi

Kim

2019

IJMS

315

230

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Reactive oxygen species (ROS) and free radicals are essential for transmission of cell signals and other physiological functions. However, excessive amounts of ROS can cause cellular imbalance in reduction–oxidation reactions and disrupt normal biological functions, leading to oxidative stress, a condition known to be responsible for the development of several diseases. The biphasic role of ROS in cellular functions has been a target of pharmacological research. Osteoclasts are derived from hematopoietic progenitors in the bone and are essential for skeletal growth and remodeling, for the maintenance of bone architecture throughout lifespan, and for calcium metabolism during bone homeostasis. ROS, including superoxide ion (O2−) and hydrogen peroxide (H2O2), are important components that regulate the differentiation of osteoclasts. Under normal physiological conditions, ROS produced by osteoclasts stimulate and facilitate resorption of bone tissue. Thus, elucidating the effects of ROS during osteoclast differentiation is important when studying diseases associated with bone resorption such as osteoporosis. This review examines the effect of ROS on osteoclast differentiation and the efficacy of novel chemical compounds with therapeutic potential for osteoclast related diseases.

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“…In addition, MMP-9 and cathepsin K are released by mature osteoclasts to degrade bone by removing bone-lining collagen [51][52][53][54] .…”

Section: Main Gene Of Osteoclastogenesis and Osteoclast Functionmentioning

confidence: 99%

Characterization of MicroRNA Expression Profiles in Patients with Giant Cell Tumor

Qin

Yan

et al. 2016

Orthopaedic Surgery

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Molecular Understanding of Osteoclast Differentiation and Physiology

Cited by 17 publications

References 64 publications

Differential Gene Expression Pattern in Osteoclast Precursor Cells of Indian Postmenopausal Women with and Without Osteoporosis: A Microarray Based Study

Differential Gene Expression Pattern in Osteoclast Precursor Cells of Indian Postmenopausal Women with and Without Osteoporosis: A Microarray Based Study

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Characterization of MicroRNA Expression Profiles in Patients with Giant Cell Tumor

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