Background: Osteoporosis is a multifactorial disease with strong genetic and epigenetic component. In spite of enormous candidate gene association studies, the etiology and molecular mechanism of disease is not fully known. For identification of new markers of osteoporosis which could be vital in diagnosis and prognosis of disease, genome-wide microarray expression approach was employed.
Gadchiroli district is majorly covered with forest, and most of the population is tribal, living in the vicinity of the forest. The district is located on the eastern side of Maharashtra. As per the 2011 India census, Gadchiroli recorded a total population of 10,71,795. Males constituted 51% of the population and females 49%. Approximately 11% of the population of Gadchiroli was under six years of age, and almost 90% of the child population stays in the rural part of Gadchiroli. Annual rainfall for the Gadchiroli district is approximately 1,000 mm in the monsoon season from June to September. Gadchiroli is a hotspot for malaria disease in Maharashtra. More than 50% of malaria cases in Maharashtra are observed in Gadchiroli. A special malaria campaign of mass survey for identification of active transmission is carried out in 15 malaria-sensitive PHCs in Gadchiroli from mid of February 2021 to the end of March 2021. About 76% population was tested by microscopic, and 11 % population was screened by Rapid Diagnostic Kit. A total of 164 asymptomatic malaria carriers were identified with 25% gametocytes. Identifying these asymptomatic transmissions followed by complete radical treatment towards malaria elimination is suggested.
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