Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases

Dhawan, Veena; Bakshi, Chetan; Rather, Riyaz Ahmad

doi:10.1007/978-981-13-8273-4_4

Cited by 2 publications

(3 citation statements)

References 183 publications

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“…Endothelial dysfunction, characterized by impaired nitric oxide (NO) production and increased oxidative stress, is a hallmark of hypertension. Quercetin has been shown to promote NO bioavailability by increasing endothelial NO synthase (eNOS) expression and inhibiting the activity of enzymes that degrade NO, such as NADPH oxidase and arginase [ 140 ]. Moreover, quercetin exerts antioxidant properties by scavenging reactive oxygen species (ROS) and decreasing oxidative stress, which can help protect endothelial cells from damage and maintain their proper function.…”

Section: Biological Activitiesmentioning

confidence: 99%

Recent Advances in Potential Health Benefits of Quercetin

Aghababaei

Hadidi

2023

Pharmaceuticals

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Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, and anticancer properties, have been extensively studied. Its strong antioxidant properties enable it to scavenge free radicals, reduce oxidative stress, and protect against cellular damage. Quercetin’s anti-inflammatory properties involve inhibiting the production of inflammatory cytokines and enzymes, making it a potential therapeutic agent for various inflammatory conditions. It also exhibits anticancer effects by inhibiting cancer cell proliferation and inducing apoptosis. Finally, quercetin has cardiovascular benefits such as lowering blood pressure, reducing cholesterol levels, and improving endothelial function, making it a promising candidate for preventing and treating cardiovascular diseases. This review provides an overview of the chemical structure, biological activities, and bioavailability of quercetin, as well as the different delivery systems available for quercetin. Incorporating quercetin-rich foods into the diet or taking quercetin supplements may be beneficial for maintaining good health and preventing chronic diseases. As research progresses, the future perspectives of quercetin appear promising, with potential applications in nutraceuticals, pharmaceuticals, and functional foods to promote overall well-being and disease prevention. However, further studies are needed to elucidate its mechanisms of action, optimize its bioavailability, and assess its long-term safety for widespread utilization.

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Section: Biological Activitiesmentioning

confidence: 99%

Recent Advances in Potential Health Benefits of Quercetin

Aghababaei

Hadidi

2023

Pharmaceuticals

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“…Oxidative stress is mainly caused by imbalanced production of reactive oxygen species (ROS) and antioxidants [ 9 , 10 ]. ROS are highly reactive chemical substances containing oxygen, controlled by the activities of specific antioxidant enzymes, such as catalase, glutathione peroxidase and superoxide dismutase [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Under normal physiological conditions, the low concentrations of ROS play an important role in cell homeostasis by regulating cell signal transduction and physiological activity [ 13 ]. However, when the production of ROS exceeds the control of the antioxidant defense mechanisms, oxidative stress will occur, hindering protein folding, damaging the synthesis and accumulating toxic products, which affect the normal function of cells and lead to cell death, and ultimately may lead to diseases in the cardiovascular system [ 9 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases

et al. 2021

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In different pathological states that cause endoplasmic reticulum (ER) calcium depletion, altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy perturbation/fluctuations, the protein folding process is disrupted and the ER becomes stressed. Studies in the past decade have demonstrated that ER stress is closely associated with pathogenesis of obesity, insulin resistance and type 2 diabetes. Excess nutrients and inflammatory cytokines associated with metabolic diseases can trigger or worsen ER stress. ER stress plays a critical role in the induction of endothelial dysfunction and atherosclerosis. Signaling pathways including AMP-activated protein kinase and peroxisome proliferator-activated receptor have been identified to regulate ER stress, whilst ER stress contributes to the imbalanced production between nitric oxide (NO) and reactive oxygen species (ROS) causing oxidative stress. Several drugs or herbs have been proved to protect against cardiovascular diseases (CVD) through inhibition of ER stress and oxidative stress. The present article reviews the involvement of ER stress and oxidative stress in cardiovascular dysfunction and the potential therapeutic implications.

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Molecular Targets and Novel Therapeutics to Target Oxidative Stress in Cardiovascular Diseases

Cited by 2 publications

References 183 publications

Recent Advances in Potential Health Benefits of Quercetin

Recent Advances in Potential Health Benefits of Quercetin

Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases

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