Recent Advances in Potential Health Benefits of Quercetin

Abstract

Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, and anticancer properties, have been extensively studied. Its strong antioxidant properties enable it to scavenge free radicals, reduce oxidative stress, and protect against cellular damage. Quercetin’s anti-inflammatory properties involve inhibiting the production of inflammatory cytokines and enzymes, making it a potential therapeutic agent for various inflammatory conditions. It also exhibits anticancer effects by inhibiting cancer cell proliferation and inducing apoptosis. Finally, quercetin has cardiovascular benefits such as lowering blood pressure, reducing cholesterol levels, and improving endothelial function, making it a promising candidate for preventing and treating cardiovascular diseases. This review provides an overview of the chemical structure, biological activities, and bioavailability of quercetin, as well as the different delivery systems available for quercetin. Incorporating quercetin-rich foods into the diet or taking quercetin supplements may be beneficial for maintaining good health and preventing chronic diseases. As research progresses, the future perspectives of quercetin appear promising, with potential applications in nutraceuticals, pharmaceuticals, and functional foods to promote overall well-being and disease prevention. However, further studies are needed to elucidate its mechanisms of action, optimize its bioavailability, and assess its long-term safety for widespread utilization.

Exploring Beneficial Properties of Haskap Berry Leaf Compounds for Gut Health Enhancement

“…Rutin and quercetin, flavonoids with diverse health-promoting effects, demonstrated concentrations ranging from 0.871 to 1.157 mg/g DL and 1.249 to 1.509 mg/g DL, respectively. These compounds have been studied for their potential effects on various health conditions, including diabetes [ 62 , 63 ]. Both rutin and quercetin are known for their potent antioxidant properties [ 64 , 65 ].…”

Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

“…High levels of quercetin are found in fruits and vegetables like apples, cranberries, grapes, onions, and capers [ 23 ]. Depending on food intake and consumption of fruits and vegetables, the dietary intake of quercetin adds up to 50 to 800 mg per day [ 15 ]. The poor aqueous solubility of quercetin has limited its pharmacologic availability [ 24 ].…”

“…Quercetin acts as a potent antioxidant by scavenging reactive oxygen species, inhibiting lipid peroxidation, and increasing the activity of antioxidant enzymes. The reduction in oxidative stress in the brain supports protection against neurodegenerative diseases [ 15 ]. Additionally, quercetin inhibits the activation of microglial cells and reduces production of proinflammatory cytokines thereby reducing inflammation in the brain and adding to the neuroprotective effects.…”

Antioxidant Activity of Flavonoid Compounds in Lime (Citrus aurantifolia) via Density Functional Theory

“…The values of these parameters can be computed from the HOMO and LUMO energy values by substituting them into eqs. (11)(12)(13)(14)(15)(16)(17)(18)(19). The calculation results are then compared for each compound to analyze the compound that is most reactive towards radicals as an indication of a good antioxidant compound.…”