Molecular survey and phylogenetic analysis of Babesia vogeli in dogs

Selim, Abdelfattah; Megahed, Ameer; Saïd, Mourad Ben; Alanazi, Abdullah D.; Sayed-Ahmed, Mohamed Z.

doi:10.1038/s41598-022-11079-x

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…In this study, B. vogeli was detected in 18 (5.34%) of 337 blood samples. The prevalence of the parasite was 2.1% in Malaysia [ 37 ], 4.8% in Brazil [ 38 ], 5.1% in Egypt [ 39 ], 5.1% in Iraq [ 40 ], 8.5% in Bosnia and Herzegovina [ 41 ], 9.3% in Iran [ 42 ], and 10.8% in Nigeria [ 43 ]. When the studies given above were evaluated, it was seen that the prevalence of B. vogeli was quite different.…”

Section: Discussionmentioning

confidence: 99%

First Molecular Evidence of Babesia vogeli, Babesia vulpes, and Theileria ovis in Dogs from Kyrgyzstan

et al. 2023

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Tick-borne parasitic diseases cause mild to severe infections among vertebrate hosts, including dogs. Species in the genus Babesia are important tick-borne pathogens and have worldwide distributions. Although there are data on the prevalence and distribution of Babesia species among dogs around the world, there is no information available in Kyrgyzstan, according to a literature review. In this study, 337 dogs were screened by nested PCR for the presence of the 18S small subunit ribosomal RNA (18S SSU rRNA) gene of piroplasm species. Overall prevalence was 6.23% (21/337) for Babesia/Theileria spp. DNA sequencing of positively tested samples revealed that eighteen samples were infected with Babesia vogeli (B. vogeli) (5.34%), two samples with B. vulpes (0.59%), and one sample with Theileria ovis (T. ovis) (0.29%). The phylogenetic analyses and nucleotide sequences in contrast with those present in GenBank revealed that two nucleotide substitutions (594th and 627th) were found between B. vogeli isolates, including ours, indicating that the mutation is relatively rare. The sequences of other pathogens obtained in this study confirmed 100% nucleotide identity with B. vulpes and T. ovis sequences in GenBank. To the best of our knowledge, B. vogeli, B. vulpes, and T. ovis were detected for the first time in dogs from Kyrgyzstan, and it is thought that results will contribute to the understanding of the epidemiology of canine tick-borne pathogens in the country.

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Section: Discussionmentioning

confidence: 99%

First Molecular Evidence of Babesia vogeli, Babesia vulpes, and Theileria ovis in Dogs from Kyrgyzstan

et al. 2023

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“…Although the authors of that study indicated other risk factors (e.g., male sex or various exotic dog breeds) [ 244 ], those parameters were not statistically insignificant ( p -values higher than 0.05), and therefore cannot be considered as risk factors for B. vogeli infection in Nigeria. A study from Egypt on the prevalence of B. vogeli infection in 275 dogs showed that the higher risk of infection in male dogs was not statistically significant [ 267 ]. The only significant risk factors for infection in dogs from Egypt were the soil type of the floor in dog shelters (OR = 6.1) in comparison to paved floors, and tick infestation (OR = 3.8) in comparison to a lack of tick infestation [ 267 ].…”

Section: Risk Factors For Large Babesia Infectionsmentioning

confidence: 99%

“…A study from Egypt on the prevalence of B. vogeli infection in 275 dogs showed that the higher risk of infection in male dogs was not statistically significant [ 267 ]. The only significant risk factors for infection in dogs from Egypt were the soil type of the floor in dog shelters (OR = 6.1) in comparison to paved floors, and tick infestation (OR = 3.8) in comparison to a lack of tick infestation [ 267 ]. However, a study from Brazil did not find an association between the type of the floor where dogs were kept and the frequency of infection with the parasite [ 241 ].…”

Section: Risk Factors For Large Babesia Infectionsmentioning

confidence: 99%

Canine Babesiosis Caused by Large Babesia Species: Global Prevalence and Risk Factors—A Review

Zygner

Gójska-Zygner²,

Bartosik

et al. 2023

Animals

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Canine babesiosis is a disease caused by protozoan pathogens belonging to the genus Babesia. Four species of large Babesia cause canine babesiosis (B. canis, B. rossi, B. vogeli, and the informally named B. coco). Although canine babesiosis has a worldwide distribution, different species occur in specific regions: B. rossi in sub-Saharan Africa, B. canis in Europe and Asia, and B. coco in the Eastern Atlantic United States, while B. vogeli occurs in Africa, southern parts of Europe and Asia, northern Australia, southern regions of North America, and in South America. B. vogeli is the most prevalent large Babesia species globally. This results from its wide range of monotropic vector species, the mild or subclinical nature of infections, and likely the longest evolutionary association with dogs. The most important risk factors for infection by large Babesia spp. include living in rural areas, kennels or animal shelters, or regions endemic for the infection, the season of the year (which is associated with increased tick activity), infestation with ticks, and lack of treatment with acaricides.

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“…Later, with the development of DNA sequencing technology and other molecular based approaches, it was found that although the morphology of these infected dogs was similar, the genes they encode for were Babesiosis, also known as piroplasmosis, is a disease caused by Babesia protozoan parasites that use variety of ticks as natural vectors (Hildebrandt et al 2021;Krause 2019). The disease is mainly transmitted by ticks when they bite the host (Selim et al 2022). Babesia proliferates and destroys the infected erythrocytes of susceptible hosts(García-Quesada et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and phylogenetic investigation of Babesia spp. in dogs of Hainan Province/Island, China

Wang,

Zu,

Upadhyay

et al. 2023

Parasitol Res

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Babesiosis is a signi cant tick borne disease, which is widely prevalent globally. Many research studies have discussed the presence of Babesia gibsoni, Babesia vogeli and Babesia canis in dogs in China. In the present study, we have used molecular approaches to detect the presence of Babesia spp. in dogs of Hainan province/island, China. A total of 1106 dog blood samples were collected from Hainan Island, of which 61 samples were found to be positive for Babesia vogeli. The highest infection rate was 56.7% (17/30) detected from Tunchang, followed by 25.0% (3/12) from Baisha and 10.4% (5/48) from Wenchang. There was only one positive case of Babesia gibsoni, and the infection rate was 0.1% (1/1106). The sequencing results showed that the subjected sample sequences were identical to Babesia vogeli and Babesia gibsoni. The results derived from this study will be helpful for planning the effective treatment, control and prevention of babesiosis in dogs of Hainan province/island.

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Molecular survey and phylogenetic analysis of Babesia vogeli in dogs

Cited by 9 publications

References 41 publications

First Molecular Evidence of Babesia vogeli, Babesia vulpes, and Theileria ovis in Dogs from Kyrgyzstan

First Molecular Evidence of Babesia vogeli, Babesia vulpes, and Theileria ovis in Dogs from Kyrgyzstan

Canine Babesiosis Caused by Large Babesia Species: Global Prevalence and Risk Factors—A Review

Epidemiological and phylogenetic investigation of Babesia spp. in dogs of Hainan Province/Island, China

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