Molecular Studies of Visna Virus Gene Expression: Analysis of Envelope Gene Expression in Transgenic Sheep

Je, Clements; Hu, Lirong; Lindstrom, Lynn; Powell, Anne M.; Rexroad, Caird E.; Mc, Zink

doi:10.1089/aid.1996.12.421

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…Two of them subsequently produced antibodies against the foreign protein. mRNA and envelope proteins were also found in several tissues such as the kidney, muscle, and brain [86].…”

Section: Random Integration Of Transgenesmentioning

confidence: 99%

Genome Editing Strategies to Protect Livestock from Viral Infections

Söllner

Mettenleiter

Petersen

2021

Viruses

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The livestock industry is constantly threatened by viral disease outbreaks, including infections with zoonotic potential. While preventive vaccination is frequently applied, disease control and eradication also depend on strict biosecurity measures. Clustered regularly interspaced palindromic repeats (CRISPR) and associated proteins (Cas) have been repurposed as genome editors to induce targeted double-strand breaks at almost any location in the genome. Thus, CRISPR/Cas genome editors can also be utilized to generate disease-resistant or resilient livestock, develop vaccines, and further understand virus–host interactions. Genes of interest in animals and viruses can be targeted to understand their functions during infection. Furthermore, transgenic animals expressing CRISPR/Cas can be generated to target the viral genome upon infection. Genetically modified livestock can thereby reduce disease outbreaks and decrease zoonotic threats.

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“…Two of them subsequently produced antibodies against the foreign protein. mRNA and envelope proteins were also found in several tissues such as the kidney, muscle, and brain [86].…”

Section: Random Integration Of Transgenesmentioning

confidence: 99%

Genome Editing Strategies to Protect Livestock from Viral Infections

Söllner

Mettenleiter

Petersen

2021

Viruses

View full text Add to dashboard Cite

show abstract

“…[133] and references cited therein). Initial studies with farm animals included the "classical" approach of overexpression of a viral protein in transgenic sheep [136], transgenic rabbits expressing antisense constructs complementary to adenovirus RNA [137], and the transfer of the specific disease resistance gene Mx1 of mice into swine [138]. The mouse Mx1 gene is one of the few examples of a single genetic locus encoding a disease resistance trait.…”

Section: Additive Gene Transfer Of Resistance Genesmentioning

confidence: 99%