Molecular Structure of the Mouse CCK-A Receptor Gene

Lacourse, Karen A.; Lay, Jean M.; Swanberg, Lisa J.; Jenkins, Casey; Samuelson, Linda C.

doi:10.1006/bbrc.1997.7030

Cited by 27 publications

(14 citation statements)

References 26 publications

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“…However, the physiological response of the small intestine to CCK has remained unclear until now. Expression of the Cck-1r gene has been found not only on smooth muscle of gallbladder and stomach, but also on smooth muscle of the small intestine (35). We observed that CCK-1R -/-mice displayed significantly slower smallintestinal transit times compared with WT mice, whether ingesting chow or the lithogenic diet.…”

Section: Discussionmentioning

confidence: 65%

Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

Wang¹,

Schmitz²,

Kopin³

et al. 2004

J. Clin. Invest.

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Cholecystokinin (CCK) modulates contractility of the gallbladder, the sphincter of Oddi, and the stomach. These effects are mediated through activation of gastrointestinal smooth muscle as well as enteric neuron CCK-1 receptors (CCK-1Rs). To investigate the potential physiological and pathophysiological functions linked to CCK-1R-mediated signaling, we compared male WT and CCK-1R-deficient mice (129/SvEv). After 12 weeks on either a standard mouse chow or a lithogenic diet (containing 1% cholesterol, 0.5% cholic acid, and 15% dairy fat), small-intestinal transit time, intestinal cholesterol absorption, biliary cholesterol secretion, and cholesterol gallstone prevalence were compared in knockout versus WT animals. Analysis of mice on either the chow or the lithogenic diet revealed that CCK-1R -/-animals had larger gallbladder volumes (predisposing to bile stasis), significant retardation of small-intestinal transit times (resulting in increased cholesterol absorption), and increased biliary cholesterol secretion rates. The elevation in bile cholesterol, coupled with a tendency toward gallbladder stasis (due to the absence of CCK-induced contraction), facilitates nucleation, growth, and agglomeration of cholesterol monohydrate crystals; this sequence of events in turn results in a significantly higher prevalence of cholesterol gallstones in the CCK-1R-null mice.

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Section: Discussionmentioning

confidence: 65%

Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

Wang¹,

Schmitz²,

Kopin³

et al. 2004

J. Clin. Invest.

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“…Two overlapping genomic phage clones were isolated. Restriction enzyme analysis and limited DNA sequencing were used to determine that the genomic fragment included exons 2-5 of the CCK-AR gene (37,38).…”

Section: Methodsmentioning

confidence: 99%

The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight

Kopin

Mathes²,

McBride³

et al. 1999

J. Clin. Invest.

226

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“…The transcriptional start site of human CCK1R was identified 206 bp upstream of the translation start site. In the mouse CCK2R gene, the transcriptional start site was identified at 199 bp upstream of the translation start site in a region devoid of any TATA-like sequences (157,262). So far, no precise data have been reported on CCKR gene regulation.…”

Section: Genesmentioning

confidence: 99%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

419

418

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Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling pathways used to exert short- and long-term effects and the structural data that explain their binding properties, activation, and regulation. We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed.

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Molecular Structure of the Mouse CCK-A Receptor Gene

Cited by 27 publications

References 26 publications

Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight

Cholecystokinin and Gastrin Receptors

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