Molecular state evaluation of active pharmaceutical ingredients in adhesive patches for transdermal drug delivery

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

“…However, there are a lot of medicines that implementation by the oral route is characterized by a low adsorption rate from the gastrointestinal tract or extensive first-pass metabolism [ 32 , 33 ]. In these examples, the skin may be an alternative route for applying drugs, as it has been widely used as a route of administration for local and systemic drugs [ 34 , 35 ]. Transport across the biological barrier creates a problem resulting from the interaction or reaction of the experimental drug with the epithelial barrier [ 36 ].…”

Pentafluorophenyl Group as Activating Group: Synthesis of α‐Deuterio Carboxylic Acid Derivatives via Et3N Catalyzed H/D Exchange

“…As shown in Scheme 4, this protocol was applied in the synthesis of various deuterated carboxylic acids. Useful deuterated building blocks (2 a [12] and 2 b [13] ) and deuterated bioactive compounds including deuterated rooton 2 c [14] deuterated antiinflammatory agent ibuprofen 2 d, [15] deuterated pain or fever reducer naproxen 2 e [16] and deuterated felbinac 2 f [17] were synthesized in high yields, which exhibited the potential application of this protocol in medicinal chemistry.…”

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

“…112,113 Due to their unique molecular structure, polyphenols can bind to proteins, metal ions, polymers, and nucleic acids, which contributes to their use as important functional components in other drug delivery strategies. [114][115][116] In addition to being an integral part of the vehicle, polyphenols are also effective in protecting the structural integrity of nanoparticles (NPs) and the biological activity of the medical intervention compounds carried by them, 117 such as by acting as a protective layer to protect nanomedicines from oxidation and improve carbohydrate polymer carriers. 118,119 As a biological ligand, curcumin (Cur) is a natural polyphenol active molecule.…”