Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy

Ellis, J. S.; Allen, Stephanie; Chim, Ya Tsz A.; Roberts, Clive J.; Tendler, Saul J. B.; Davies, Martyn C.

doi:10.1007/12_027

Cited by 12 publications

(5 citation statements)

References 225 publications

(436 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, inner structural information, such as the lamella architecture within the starch, can be obtained of intact polymers (structural level 2, Table 1) by various X-ray techniques, especially small-and wide-angle scattering (SAXS and WAXS, respectively; [74,75]) and X-ray diffraction (XRD; [72]). Atomic force microscopy (AFM) has also been applied to starch analysis [73,[76][77][78][79][80][81][82][83]. AFM allows to determine the properties of starch surface structures, including starch modifications on the surface.…”

Section: Analysis Of Entire Starch Particles and Glycogen Moleculesmentioning

confidence: 99%

Starch and Glycogen Analyses: Methods and Techniques

2020

View full text Add to dashboard Cite

For complex carbohydrates, such as glycogen and starch, various analytical methods and techniques exist allowing the detailed characterization of these storage carbohydrates. In this article, we give a brief overview of the most frequently used methods, techniques, and results. Furthermore, we give insights in the isolation, purification, and fragmentation of both starch and glycogen. An overview of the different structural levels of the glucans is given and the corresponding analytical techniques are discussed. Moreover, future perspectives of the analytical needs and the challenges of the currently developing scientific questions are included.

show abstract

Section: Analysis Of Entire Starch Particles and Glycogen Moleculesmentioning

confidence: 99%

Starch and Glycogen Analyses: Methods and Techniques

2020

View full text Add to dashboard Cite

show abstract

“…The monitoring of the dynamics in this case provided a rationalization for the drug release kinetics in acidic environments. Finally, it is also important to mention atomic force microscopy (AFM) techniques, which are capable of acquiring a range of physicochemical information on a wide range of bioconjugates (103).…”

Section: The Importance Of An Exhaustive Physico-chemical Characterizmentioning

confidence: 99%

Polymer-drug conjugates: current status and future trends

Greco

Vicent²

2008

Front Biosci

102

View full text Add to dashboard Cite

Polymer conjugates are nano-sized, multi-component constructs already in the clinic as anticancer compounds, both as single agents or as elements of combinations. They have the potential to improve pharmacological therapy of a variety of solid tumors. Polymer-drug conjugation promotes passive tumor targeting by the enhanced permeability and retention (EPR) effect and allows for lysosomotropic drug delivery following endocytic capture. In the first part of this review, we analyze the promising results arising from clinical trials of polymer-bound chemotherapy. The experience gained on these studies provides the basis for the development of a more sophisticated second-generation of polymer conjugates. However, many challenges still lay ahead providing scope to develop and refine this field. The ''technology platform'' of polymer therapeutics allows the development of both new and exciting polymeric materials, the incorporation of novel bioactive agents and combinations thereof to address recent advances in drug therapy. The rational design of polymer drug conjugates is expected to realize the true potential of these "nanomedicines".

show abstract

“…An FDC curve is generated due to the deflection in the cantilever tip which helps in determining the maximum adhesion force. A typical Force-Displacement curve is shown in Figure 1 [24,25]. Finally, Micro-Raman spectroscopy was performed on a 10 N worn surface using CNI MGL-U-532 equipped with High Stability DPSS Laser (532 nm), Chinato understand the crystallinity on the worn surfaces.…”

Section: Methodsmentioning

confidence: 99%

Tribological Evaluation of Lead-Free MoS2-Based Solid Film Lubricants as Environmentally Friendly Replacements for Aerospace Applications

et al. 2022

View full text Add to dashboard Cite

Solid lubricants, such as MoS2 have been widely used in the aerospace industry with the primary purpose of reducing the friction and wear of tribological interfaces. MoS2 based solid film lubricants are generally doped with other compounds, which can help overcome some of their limitations related to environmental conditions. For instance, compounds like Sb2O3 and Pb have been traditionally used to improve the endurance life of these lubricants. However, with the recent zest in transferring to eco-friendly lubricants, there is a strong push to eliminate Pb based compounds. The main purpose of this work is to better understand the influence of Pb based compounds on the tribological behavior of MoS2 based solid film lubricants as well as to critically evaluate the performance of Pb free lubrication strategies. More specifically, the baseline ‘non-green’ lubricant was doped with Pb compound and Sb2O3 and the Pb compound in the ‘Green’ alternative lubricant was replaced by more Sb2O3. The wear test was done using a ball-on-disk tribometer for specific loads and for 5000 cycles. Ex-situ analysis was conducted using Scanning Electron Microscope (SEM), Atomic Force Microscopy (AFM), and micro-Raman to capture the interfacial processes of these lubricants at different loads. Overall, the non-green lubricant performed better in terms of the tribological behavior (i.e., lower friction and wear), which was attributed to the formation of a dense MoS2-based tribo-/transfer-film with the basal planes oriented in the parallel direction to the sliding. The finding on the interfacial phenomena provided critical insights into the development of novel green alternatives that may have the ability to replace Pb based compounds in the future for a sustainable environment.

show abstract

Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy

Cited by 12 publications

References 225 publications

Starch and Glycogen Analyses: Methods and Techniques

Starch and Glycogen Analyses: Methods and Techniques

Polymer-drug conjugates: current status and future trends

Tribological Evaluation of Lead-Free MoS2-Based Solid Film Lubricants as Environmentally Friendly Replacements for Aerospace Applications

Contact Info

Product

Resources

About