Molecular requirements of lignin–carbohydrate complexes for expression of unique biological activities

Sakagami, Hiroshi; Hashimoto, Ken; Suzuki, Fumiyuki; Ogiwara, Takako; Satoh, Kazue; Ito, Hideyuki; Hatano, Tsutomu; Yoshida, Takashi; Fujisawa, Sei Ichiro

doi:10.1016/j.phytochem.2005.05.013

Cited by 62 publications

(42 citation statements)

References 34 publications

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“…Pine cone lignin-carbohydrate complexes have also been reported to show antiviral effects against HIV-1, influenza virus and HSV. 20) In addition, the lignin-carbohydrate complexes from pine cone possess various biological activities including immunopotentiation. Kiyohara et al have also reported that lignin-carbohydrate complexes in the kampo (Japanese herbal) medicine, juzen-taiho-to, modulated the intestinal immune system.…”

Section: Discussionmentioning

confidence: 99%

Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes fromPimpinella anisum

Lee

Yamagishi

Hayashi

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes fromPimpinella anisum

Lee

Yamagishi

Hayashi

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…Recently, LCC as a biological material has attracted attention. Many researchers have found that lignin-carbohydrate complexes are a good natural biodegradable material [10,11]. In addition, LCC contains hydrophobic rigid lignin blocks and hydrophilic flexible polysaccharide blocks, making lignin-carbohydrate complexes have good amphipathy, biocompatibility, and mechanical strength [12].…”

Section: Introductionmentioning

confidence: 99%

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Zhao

Wang

et al. 2017

International Journal of Polymer Science

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Spherical biocarriers were prepared with lignin-carbohydrate complexes isolated from ginkgo (Ginkgo biloba L.) xylem. The specific surface and average pore size of the biocarriers were 17.15 m 2 g −1 and 21.59 nm, respectively. The carriers were stable in solution at pH 4.0∼9.5. Fourier transform infrared (FT-IR) spectrum indicated that the spherical carrier was composed of lignin and polysaccharides and had a typical lignin-carbohydrate complex (LCC) structure. The contents of galactose, lignin, and total sugar were 3.30%, 23.9%, and 64.62%, respectively, making the spherical biocarriers have good physical strength and compatible with hepatocytes. It was observed using a scanning electron microscopy (SEM) that liver cells adhered to the spherical biocarriers during culture. Cell counting indicated that the proliferation of liver cells in the experimental group was significantly higher than that of the control group. The albumin secretion (ALB) value and glucose consumption of the human hepatocytes were increased by 51.7% and 38.6%, respectively, by the fourth day when cultivated on the biocarriers. The results indicate that ginkgo LCC is very biocompatible and shows promise for the use as a biomaterial in the culture of human hepatocytes.

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“…et Zucc enhanced the radical intensity and cytotoxicity of sodium ascorbate. On the other hand, lower concentrations of LCC stimulated the superoxide anion (O 2 -), hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of sodium ascorbate (Sakagami et al, , 2005(Sakagami et al, , 2008 . This suggests the possible application of LCC as stimulator of vitamin C action, especially in the field of UV protection and anti-aging research.…”

Section: Resultsmentioning

confidence: 99%

“…Varying the ratio of polysaccharide to phenylpropenoid polymer produces heterogeneity in the acidity, water-solubility, ethanol-insolubility, and molecular weight of LCC that might strongly affect its antiviral potency (Sakagami, et al, 2005(Sakagami, et al, , 2010b. However, this possibility has not been tested yet by any investigators.…”

Section: Immune Evasionmentioning

confidence: 99%

Treatment of Herpes Simplex Virus with Lignin-Carbohydrate Complex Tablet, an Alternative Therapeutic Formula

López¹,

Yamamoto²,

Sakagami³

2012

Antiviral Drugs - Aspects of Clinical Use and Recent Advances

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Molecular requirements of lignin–carbohydrate complexes for expression of unique biological activities

Cited by 62 publications

References 34 publications

Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes fromPimpinella anisum

Antiviral and Immunostimulating Effects of Lignin-Carbohydrate-Protein Complexes fromPimpinella anisum

Lignin-Carbohydrate Complexes Based Spherical Biocarriers: Preparation, Characterization, and Biocompatibility

Treatment of Herpes Simplex Virus with Lignin-Carbohydrate Complex Tablet, an Alternative Therapeutic Formula

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