Molecular Recognition by Inclusion Crystals of Chiral Host Molecules Having Trityl and Related Bulky Groups

Enantiomer Separation of Nitriles and Epoxides by Crystallization with Chiral Organic Salts: Chirality Switching Modulated by Achiral Acids

“…Enantiomer separation of a racemate by enantioselective inclusion crystal formation with chiral host compounds is one of the most efficient methods to access enantiopure compounds. , Intermolecular interactions, such as hydrogen bonds between host and guest molecules, are often necessary to promote inclusion of guest compounds. Enantioseparation of hydrogen-donating compounds such as alcohols and amides as guest compounds has been well studied because most of them are recognized by multi-point hydrogen bonds . However, compounds with only a hydrogen-accepting site (ketones, esters, etc.)…”

“…Enantioseparation of hydrogendonating compounds such as alcohols and amides as guest compounds has been well studied because most of them are recognized by multi-point hydrogen bonds. 3 However, compounds with only a hydrogen-accepting site (ketones, esters, etc.) have been less investigated because of their difficulty to capture.…”