Molecular prospect of type-2 diabetes: Nanotechnology based diagnostics and therapeutic intervention

Kerry, Rout George; Mahapatra, Gyana Prakash; Maurya, Ganesh Kumar; Patra, Sushmita; Mahari, Subhasis; Das, Gitishree; Patra, Jayanta Kumar; Sahoo, Sabuj

doi:10.1007/s11154-020-09606-0

Cited by 17 publications

(7 citation statements)

References 251 publications

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“…Nanotechnology has led to the development of various NP formulations for diagnostic applications, thereby revolutionizing treatment strategies of relevant diseases, whose outcomes depend on early and accurate detection, such as cancer [ 25 , 336 , 426 , 578 , 579 ], diabetes [ 580 , 581 , 582 ], gastrointestinal disorders [ 583 , 584 , 585 ], infectious diseases [ 586 , 587 , 588 , 589 ], and neurodegenerative disorders [ 590 , 591 , 592 ]. Imaging and point-of-care technologies are two specific fields that could benefit from the utilization of NPs [ 593 , 594 ].…”

Section: Biomedical Applications Of Biogenic Selenium Nanoparticlesmentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

et al. 2023

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Selenium is an important dietary supplement and an essential trace element incorporated into selenoproteins with growth-modulating properties and cytotoxic mechanisms of action. However, different compounds of selenium usually possess a narrow nutritional or therapeutic window with a low degree of absorption and delicate safety margins, depending on the dose and the chemical form in which they are provided to the organism. Hence, selenium nanoparticles (SeNPs) are emerging as a novel therapeutic and diagnostic platform with decreased toxicity and the capacity to enhance the biological properties of Se-based compounds. Consistent with the exciting possibilities offered by nanotechnology in the diagnosis, treatment, and prevention of diseases, SeNPs are useful tools in current biomedical research with exceptional benefits as potential therapeutics, with enhanced bioavailability, improved targeting, and effectiveness against oxidative stress and inflammation-mediated disorders. In view of the need for developing eco-friendly, inexpensive, simple, and high-throughput biomedical agents that can also ally with theranostic purposes and exhibit negligible side effects, biogenic SeNPs are receiving special attention. The present manuscript aims to be a reference in its kind by providing the readership with a thorough and comprehensive review that emphasizes the current, yet expanding, possibilities offered by biogenic SeNPs in the biomedical field and the promise they hold among selenium-derived products to, eventually, elicit future developments. First, the present review recalls the physiological importance of selenium as an oligo-element and introduces the unique biological, physicochemical, optoelectronic, and catalytic properties of Se nanomaterials. Then, it addresses the significance of nanosizing on pharmacological activity (pharmacokinetics and pharmacodynamics) and cellular interactions of SeNPs. Importantly, it discusses in detail the role of biosynthesized SeNPs as innovative theranostic agents for personalized nanomedicine-based therapies. Finally, this review explores the role of biogenic SeNPs in the ongoing context of the SARS-CoV-2 pandemic and presents key prospects in translational nanomedicine.

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Section: Biomedical Applications Of Biogenic Selenium Nanoparticlesmentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

et al. 2023

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“…Up to now, nanotechnology has been widely investigated for the prevention, diagnosis, and treatment of DM and its complications, as previously reviewed in detail in several articles [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. Nanotechnology has aided in the diagnosis of DM, as the early detection of this disease or knowledge of its exact stage of progression is essential for its management and for the prevention of its potentially fatal complications.…”

Section: Application Of Nanotechnology In Dmmentioning

confidence: 99%

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

et al. 2023

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Diabetes mellitus (DM) is a metabolic disease characterized by abnormal blood glucose levels-hyperglycemia, caused by a lack of insulin secretion, impaired insulin action, or a combination of both. The incidence of DM is increasing, resulting in billions of dollars in annual healthcare costs worldwide. Current therapeutics aim to control hyperglycemia and reduce blood glucose levels to normal. However, most modern drugs have numerous side effects, some of which cause severe kidney and liver problems. On the other hand, natural compounds rich in anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin) have also been used for the prevention and treatment of DM. However, lack of standardization, poor stability, unpleasant taste, and decreased absorption leading to low bioavailability have hindered the application of anthocyanins as therapeutics. Therefore, nanotechnology has been used for more successful delivery of these bioactive compounds. This review summarizes the potential of anthocyanins for the prevention and treatment of DM and its complications, as well as the strategies and advances in the delivery of anthocyanins using nanoformulations.

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“…As a result, the development of specific, sensitive and reliable technologies for quick detection is always needed for Salmonella diagnosis. Biosensors provide a number of advantages over laboratory-based assays, including increased sensitivity accuracy and specificity as well as the low cost, rapid response, in situ applications and potential for portability [ 5 , 6 , 7 , 8 , 9 ]. As a result, they have been identified as impressive alternatives for detecting Salmonella in food.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Electrochemical Biosensors for the Detection of Salmonellosis: Current Prospective and Challenges

Mahari

Gandhi

2022

Biosensors

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Salmonellosis is a major cause of foodborne infections, caused by Salmonella, posing a major health risk. It possesses the ability to infiltrate the food supply chain at any point throughout the manufacturing, distribution, processing or quality control process. Salmonella infection has increased severely and requires effective and efficient methods for early monitoring and detection. Traditional methods, such as real-time polymerase chain reaction and culture plate, consume a lot of time and are labor-intensive. Therefore, new quick detection methods for on-field applications are urgently needed. Biosensors provide consumer-friendly approaches for quick on-field diagnoses. In the last few years, there has been a surge in research into the creation of reliable and advanced electrochemical sensors for the detection of Salmonella strains in food samples. Electrochemical sensors provide extensive accuracy and reproducible results. Herein, we present a comprehensive overview of electrochemical sensors for the detection of Salmonella by focusing on various mechanisms of electrochemical transducer. Further, we explain new-generation biosensors (microfluidics, CRISPR- and IOT-based) for point-of care applications. This review also highlights the limitations of developing biosensors in Salmonella detection and future possibilities.

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Molecular prospect of type-2 diabetes: Nanotechnology based diagnostics and therapeutic intervention

Cited by 17 publications

References 251 publications

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

Recent Advances in Electrochemical Biosensors for the Detection of Salmonellosis: Current Prospective and Challenges

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