Molecular phylogenetics and taxonomy of the African mole-rats, genus Cryptomys and the new genus Coetomys Gray, 1864

Ingram, Colleen M.; Burda, Hynek; Honeycutt, Rodney L.

doi:10.1016/j.ympev.2003.11.004

Cited by 81 publications

(156 citation statements)

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“…Fukomys (synonym Coetomys nomen invalidus; Kock et al, 2006) forms a northern clade within a phylogroup (Cryptomys sensu lato) that further contains the reciprocally monophyletic Cryptomys sensu stricto clade of southern Africa. Two recent phylogenetic analyses using nuclear and mitochondrial DNA sequences, combined with data on chromosomal variation, unambiguously support the taxonomic division of Cryptomys and Fukomys, although these data do not resolve the relationships within Fukomys Ingram et al, 2004). To date no less than 12 Fukomys species are accepted as valid.…”

Section: Phylogenetic Analyses Chromosomal Diversification and Classmentioning

confidence: 93%

“…Furthermore, Van Daele et al (2004) recently described 9 new chromosomal races within the Zambezian clade (i.e. the mechowi (sic) group of Ingram et al, 2004), illustrating that south-central Zambia forms a ''hotspot of karyotypical diversity''. The evolutionary mechanisms behind chromosomal diversity within Fukomys remain poorly understood.…”

Section: Phylogenetic Analyses Chromosomal Diversification and Classmentioning

confidence: 99%

“…The compiled sequences were subsequently aligned using ClustalW (Thompson et al, 1994) in MEGA v3.0 (Kumar et al, 2004). Based on previous studies Ingram et al, 2004), other bathyergids, five Cryptomys species and Bathyergus suillus (Table 1) were included as outgroup taxa. Calculation of genetic distances and both maximum parsimony (MP) analysis and two probabilistic approaches, maximum likelihood (ML) and Bayesian analyses, were performed on the complete dataset.…”

Section: Sequence and Phylogenetic Analysesmentioning

confidence: 99%

“…There are only a few reliable calibration points to estimate divergence time in the derived lineages of the Bathyergidae (for a review of fossil data, see Faulkes et al, 2004). Following Ingram et al (2004), who estimated the divergence of Cryptomys and Fukomys between approximately 10 and 11 Mya, using NPRS on a combined data set of the mitochrondrial 12s ribosomal RNA and the nuclear transthyretin (TTR) gene, we used 10 and 11 Mya as calibration points in our analyses.…”

Section: Estimation Of Divergence Timementioning

confidence: 99%

“…Hazell et al, 2000;Greeff and Bennett, 2000;Burland et al, 2002Burland et al, , 2004Barnett et al, 2003;Ganem and Bennett, 2004). It may be expected that, in addition to the confamiliar naked molerat (Heterocephalus glaber), this group of African mole-rats will be of particular interest for gerontological research, taking into account longevity quotients similar to those of humans (Buffenstein, 2005;Dammann and Burda, 2006) combined with the differential levels of chromosomal and mitochondrial DNA sequence divergence, which is emphasized by the sequences available to date (Faulkes et al, 1997Ingram et al, 2004; this paper).…”

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confidence: 93%

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Cytochrome b sequence analysis reveals differential molecular evolution in African mole-rats of the chromosomally hyperdiverse genus Fukomys (Bathyergidae, Rodentia) from the Zambezian region

Daele

Verheyen

Brunain

et al. 2007

Molecular Phylogenetics and Evolution

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African mole-rats (Bathyergidae, Rodentia) of the (eu)social genus Fukomys are one of the most speciose mammal genera endemic to Sub-Saharan Africa. Fukomys distributed in the Zambezian phytochorion is characterized by extreme chromosomal variation (2n = 40-78). We inferred a molecular phylogeny of Zambezian Fukomys to resolve the interrelationships and the evolutionary history of the known chromosomal races. We sequenced the entire cytochrome b gene (1140 bp) for a total of 66 specimens representing 18 karyotypical races from Zambia. An additional 31 sequences were retrieved from GenBank including data on all other chromosomal races. The haplotypes belonging to a small chromosomal race from Salujinga cluster with the Fukomys mechowii (Giant mole-rat) haplotypes. Differential degrees of chromosomal variation are observed among the major mole-rat clades, which is most pertinent when comparing the central Zambezian Fukomys micklemi and the northern Zambezian Fukomys whytei clades. The karyotypically hyper-diverse (12 known chromosomal races) Fukomys micklemi clade shows low levels of cytochrome b sequence divergence. Within the F. whytei clade we find a more conservative pattern of chromosomal diversification (three known chromosomal races) while the levels of sequence divergence are much higher then in the F. micklemi clade. Our results suggest that chromosomal changes may drive phyletic divergence and, eventually, speciation. The observed cladogenetic events during the Plio-Pleistocene within the F. mechowii, F. whytei, F. damarensis and F. micklemi clades appear to coincide with climatically mediated speciation bursts in other savannah dwelling mammals, including hominids. Based on the molecular data presented, combined with morphological and chromosomal data, the taxonomic implication seems to be that Fukomys may contain several (undescribed) cryptic species.

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Section: Phylogenetic Analyses Chromosomal Diversification and Classmentioning

confidence: 93%

Section: Phylogenetic Analyses Chromosomal Diversification and Classmentioning

confidence: 99%

Section: Sequence and Phylogenetic Analysesmentioning

confidence: 99%

Section: Estimation Of Divergence Timementioning

confidence: 99%

mentioning

confidence: 93%

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Cytochrome b sequence analysis reveals differential molecular evolution in African mole-rats of the chromosomally hyperdiverse genus Fukomys (Bathyergidae, Rodentia) from the Zambezian region

Daele

Verheyen

Brunain

et al. 2007

Molecular Phylogenetics and Evolution

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The naked mole‐rat ( Heterocephalus glaber )

Faulkes

2024

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

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Specific paucity of unmyelinated C‐fibers in cutaneous peripheral nerves of the African naked‐mole rat: Comparative analysis using six species of bathyergidae

Smith

Purfürst

Grigoryan

et al. 2012

J of Comparative Neurology

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In mammalian peripheral nerves, unmyelinated C-fibers usually outnumber myelinated A-fibers. By using transmission electron microscopy, we recently showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber deficit manifested as a substantially lower C:A-fiber ratio compared with other mammals. Here we determined the uniqueness of this C-fiber deficit by performing a quantitative anatomical analysis of several peripheral nerves in five further members of the Bathyergidae mole-rat family: silvery (Heliophobius argenteocinereus), giant (Fukomys mechowii), Damaraland (Fukomys damarensis), Mashona (Fukomys darlingi), and Natal (Cryptomys hottentotus natalensis) mole-rats. In the largely cutaneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio (∼1.5:1 compared with ∼3:1), whereas, in nerves innervating both skin and muscle (common peroneal and tibial) or just muscle (lateral/medial gastrocnemius), this pattern was mostly absent. We asked whether lack of hair follicles alone accounts for the C-fiber paucity by using as a model a mouse that loses virtually all its hair as a consequence of conditional deletion of the β-catenin gene in the skin. These β-catenin loss-of function mice (β-cat LOF mice) displayed only a mild decrease in C:A-fiber ratio compared with wild-type mice (4.42 compared with 3.81). We suggest that the selective cutaneous C-fiber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack of skin hair follicles. Possible mechanisms contributing to this unique peripheral nerve anatomy are discussed. J. Comp. Neurol. 520:2785–2803, 2012. © 2012 Wiley Periodicals, Inc.

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Molecular phylogenetics and taxonomy of the African mole-rats, genus Cryptomys and the new genus Coetomys Gray, 1864

Cited by 81 publications

References 36 publications

Cytochrome b sequence analysis reveals differential molecular evolution in African mole-rats of the chromosomally hyperdiverse genus Fukomys (Bathyergidae, Rodentia) from the Zambezian region

Cytochrome b sequence analysis reveals differential molecular evolution in African mole-rats of the chromosomally hyperdiverse genus Fukomys (Bathyergidae, Rodentia) from the Zambezian region

The naked mole‐rat ( Heterocephalus glaber )

Specific paucity of unmyelinated C‐fibers in cutaneous peripheral nerves of the African naked‐mole rat: Comparative analysis using six species of bathyergidae

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