Molecular Phylogenetic Analysis of Iranian HDV Complete Genome

Behzadian, Farida; Sabahi, Farzaneh; Karimi, Mohsen; Sadeghizadeh, Majid; Maghsoudi, Nader; Sarrami‐Forooshani, Ramin; Shahinsaz, Leila

doi:10.1007/s11262-004-6782-z

Cited by 16 publications

(13 citation statements)

References 30 publications

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“…Ninety-six articles were found in the literature review, 40 of which [4][10][11][12][13][15][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] were potentially related to HDV prevalence in Iran. The detailed search process is demonstrated in Diagram 1.…”

Section: Resultsmentioning

confidence: 99%

Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Amini

Alavian²,

Kabir

et al. 2012

Hepat Mon

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ContextHepatitis delta virus (HDV) leads to the most severe form of chronic viral hepatitis.ObjectivesTo determine the prevalence of HDV and create pooled estimations of possible risk factors, a systematic review was conducted to collect all epidemiological studies on HDV among chronic hepatitis B patients in Iran.Data SourcesIn this systematic review, databases such as PubMed, Embase, ISI, Google scholar, and Iranian databases (MagIran, Iranmedex, and SID) were searched.Study SelectionStudies that clearly stated information about the number of HBsAg positive patients infected with HDV were selected.Data ExtractionThe name of the city, the author's name, year of study, HDV detection method, sample size, HBsAg positive frequency, mean age, total prevalence of HDV, and risk factors were extracted.ResultsThe pooled HDV prevalence was 7.8% (95% CI: 5.89 - 9.71). In the survey-data analysis, HDV prevalence was 6.61%. HDV prevalence was 30.47% (95% CI: 9.76 to 51.19), 14.4% (95% CI: 7.72 to 21.07), and 4.94% (95% CI: 3.73 to 6.15) in cirrhotic, chronic-hepatitis, and inactive-carrier patients, respectively. Pooled ORs were calculated for several factors common to Iranian HBsAg-positive patients, including history of blood transfusion [OR: 1.1 (95% CI: 0.40 to 2.98)], intravenous drug abuse [OR: 1.6 (95% CI: 0.78 to 3.21)], previous hemodialysis [OR: 1.72 (95% CI: 0.79 to 3.76)], and HBeAg-positive status [OR: 1.26 (95% CI: 0.66 to 2.4)].ConclusionsThe prevalence of HDV is less common in Iran than in endemic regions such as Italy and Turkey; however, it is a severe form of hepatitis in HBsAg-positive patients. The most probable route of HDV transmission is hematologic, which suggests the importance of blood screening for HDV, especially in groups with numerous blood transfusions.

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Section: Resultsmentioning

confidence: 99%

Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Amini

Alavian²,

Kabir

et al. 2012

Hepat Mon

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“…Up to now, there is no report of the distribution of HDV genotypes from the Iranian population, and little is known about HDV genotypes in Iran except for the survey from Behzadian et al [2005]. In that survey, the entire genome of the HDV isolate from an Iranian patient was analyzed, and the virus was shown to belong to genotype I of HDV.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of hepatitis delta virus (HDV) in Iran: A preliminary report

Mohebbi

Zali

Derakhshan

et al. 2008

Journal of Medical Virology

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To identify hepatitis delta virus (HDV) genetic variability and its circulating genotypes amongst infected Iranian patients, 25 patients with positive anti-HDV status from different parts of Iran were enrolled in this cross-sectional study. A portion of the HDV delta antigen was amplified, sequenced, and subjected to molecular and phylogenetic analysis. Clinical features and virological markers were evaluated. HDV RNA could be detected in 88% of anti-HDV positive cases (22 patients) with chronic hepatitis B virus (HBV) infection and liver cirrhosis. Phylogenetic analysis revealed that all Iranian patients were infected by genotype I (clade 1) of HDV, supported by a high bootstrap value (100%, 1,000 replicates). All HDV-positive patients were coinfected with genotype D1 of HBV. No significant association was determined between demographic, clinical, and virological variables in the population studied. In conclusion, the present molecular epidemiology survey reveals that clade 1 of HDV is predominant among coinfected HBV patients in Iran.

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“…Genotype 1 has been distributed worldwide, whereas other HDV genotypes circulate unevenly. The prevalence of HDV in Iranian hepatitis B infected individuals reported to be between 2.5% and 5.8% (5-7), and the major genotype was genotype I (8, 9). …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis Delta Virus (HDV) Infection in Chronic Hepatitis B Patients with Unusual Clinical Pictures

et al. 2013

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BackgroundProbably 5% of the HBV carriers have HDV super infection. The risk of fulminant hepatitis, cirrhosis and hepatocellular carcinoma is higher in superinfection than the settings when HBV is alone.ObjectivesThe aim of this study was to evaluate the prevalence of HDV in Iranian HBV isolates and to compare their clinical and virological pictures as well as their HDV genetic variations with other worldwide isolates.Patients and Methods81 carriers with positive results for HBsAg with upper limit ranges of ALT and low or undetectable levels of HBV viral load who did not respond to HBV therapy were selected. After RT amplification of HDV Delta antigen, direct sequencing and phylogenetic study were performed to explore the genotype(s) and nucleotide/amino acid variations.Results12 (14.8%) patients had positive results for both HDV RNA and anti-HDV. The mean ALT level was higher in HDV positive patients (75.9 U/ML) than HBV-mono-infected individuals; however, the mean HBV viral load was lower in coinfected patients than HBV-mono-infected patients. Phylogenetically, genotype I was the only detected genotype, and the most closely related isolates were of Turkish, Italian and Mongolian origin. Within the delta Ag, there were 326 nucleotide mutations, of which 111 and 215 were silent and missense, respectively. The total number of amino acid substitution was 148; most were located in known functional/epitopic domains. There was no correlation between the numbers of amino acid mutations, with clinical, virological status of the patients.ConclusionsHDV should be suspected in HBV carriers with unusual clinical and virological pictures. Relatedness of Iranian HDV isolates to Italian and Turkish sequences proposed a common Caucasian origin for the distribution of HDV genotype I in this ethnic group.

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Molecular Phylogenetic Analysis of Iranian HDV Complete Genome

Cited by 16 publications

References 30 publications

Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Molecular epidemiology of hepatitis delta virus (HDV) in Iran: A preliminary report

Prevalence of Hepatitis Delta Virus (HDV) Infection in Chronic Hepatitis B Patients with Unusual Clinical Pictures

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