2022
DOI: 10.1007/s43440-022-00443-3
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Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen

Abstract: Background Long-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding effects. Here, we studied the influence of an escalating-dose cocaine regimen on drug-associated appetitive behavior after a withdrawal period, along with corresponding molecular changes in plasma and the prefrontal cortex (PFC). Methods We applied a 5 day escalating-dose cocaine regimen in rats. We assessed anxiety… Show more

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