2008
DOI: 10.1016/j.mce.2007.11.027
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Molecular pathology of the FSH receptor: New insights into FSH physiology

Abstract: Please cite this article as: Meduri, G., Bachelot, A., Cocca, M.P., Vasseur, C., Rodien, P., Kuttenn, F., Touraine, P., Misrahi, M., Molecular Pathology of the FSH receptor: new insights into FSH physiology, Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of … Show more

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Cited by 78 publications
(69 citation statements)
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“…This observation suggested a limited FSH effect to be sufficient for promoting follicular growth up to the small antral stage. This is in line with Meduri et al, 19 who hypothesized the absolute requirement of FSH for follicular development starting from the primary stage in humans, in contrast to the initial gonadotrophin-independent follicular growth before the preantralearly antral stages observed in rodents.…”
Section: Discussionsupporting
confidence: 91%
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“…This observation suggested a limited FSH effect to be sufficient for promoting follicular growth up to the small antral stage. This is in line with Meduri et al, 19 who hypothesized the absolute requirement of FSH for follicular development starting from the primary stage in humans, in contrast to the initial gonadotrophin-independent follicular growth before the preantralearly antral stages observed in rodents.…”
Section: Discussionsupporting
confidence: 91%
“…7,9,19 In these patients, the ovaries were of normal size containing follicles developed up to the early antral stages. This observation suggested a limited FSH effect to be sufficient for promoting follicular growth up to the small antral stage.…”
Section: Discussionmentioning
confidence: 85%
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“…If the structure of the FSH receptors and their role in spermatogenesis are well known (reviewed in Huhtaniemi, 2000;Meduri et al, 2008), its cellular and intracellular distribution is questionable. Previous data, using antibodies directed against the receptor peptide complex, described its presence at the plasma membrane of Sertoli cells (Dattatreyamurty and Reichert, 1993;Beau et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…L'action conjointe de la testostérone et de la FSH s'exerce sur les cellules de Sertoli qui délimitent la paroi des tubes dique nous offre l'opportunité de mieux comprendre la physiologie humaine. Les répercussions de mutations des récep-teurs de la LH (LHR) et de la FSH, ou de leurs ligands hormonaux correspondants, ont permis d'identifier certains syndromes et de mieux comprendre l'action physiologique des hormones sur leurs organes cibles [3]. Des mutations de la LH inactivant complètement la fonction de l'hormone ont été retrouvées chez cinq patients [4][5][6][7].…”
Section: Contrôle Hormonal De La Spermatogenèse : Rôle Classique De Lunclassified