Abstract:Angiotensin I (Ang-I)-converting enzyme (ACE) is a chloridedependent zinc metallopeptidase that is important in the regulation of cardiovascular functions. In addition to Ang-I and bradykinin, ACE is able to cleave several other peptides, such as neurotensin (NT), substance P, and Angiotensin-(1-7) (Ang-1-7). We have investigated by computational methods the structural and dynamical similarities among these peptides that could be responsible to their molecular recognition by ACE. Conformational and clustering … Show more
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