Molecular Modeling, Ionic Liquid Cu(II)‐Catalyzed Synthesis of 9‐(3‐Fluoro‐4‐methoxyphenyl)‐6‐aryl‐[1,2,4]triazolo[4,3‐a][1,8] Naphthyridines under Microwave Irradiation and Their Antimicrobial Activity
Abstract:A highly efficient and simple procedure has been developed for the synthesis of 9‐(3‐fluoro‐4‐methoxyphenyl)‐6‐aryl‐[1,2,4]triazolo[4,3‐a][1,8] naphthyridines by ionic liquid Cu(II) oxidative cyclization of 2‐(2‐(3‐fluoro‐4‐methoxybenzylidene)hydrazinyl)‐3‐phenyl‐1,8‐naphthyridine under microwave irradiation. Synthesized compounds have been described by microanalysis, infrared, 1H NMR spectroscopy, and mass spectrometry. Sixteen of the synthesized compounds were evaluated for their antimicrobial activity again… Show more
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