Molecular Mechanisms Underlying Stress Response and Resilience

Kageyama, Kazunori; Nemoto, Tetsuo

doi:10.3390/ijms23169007

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Наиболее важные из них -следующие: адаптировать функциональную активность сердечно-сосудистой системы, активировать энергетические депо, поддержать адекватную гидратацию тканей. При этом физическая нагрузка играет роль стрессовой реакции, а реакция организма представляет собой ответ на возникший триггер [5].…”

Section: Introductionunclassified

The impact of physical exercise on the endocrine system in men: A review

Berkovskaya,

Elmurzaeva,

Edaev

et al. 2024

Consilium Medicum

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The endocrine system regulates many functions of the human body to maintain optimal performance and homeostasis of various organs and systems. Playing sports and various physical activities changes the regulatory function of the endocrine organs in the form of successive phases, and the magnitude of the response depends on the intensity and duration of the physical stress exerted. Hormonal regulation during physical activity facilitates the adaptation of the functional activity of the cardiovascular system, the activation of energy depots, and the maintenance of adequate tissue hydration. Physical activity leads to an increase in the production of growth hormone, insulin-like growth factor-1, total and free testosterone, which enhances the anabolic reactions of the body. It is important to understand the relationship and impact of physical activity on the functioning of the endocrine system for the development of physical exercise’s complexes, patient rehabilitation, research and treatment of endocrine disorders. The effect of physical activity on the endocrine system for women has been studied to a greater extent, in contrast to men, where the data is contradictory. Therefore, in this article we will highlight the features of various endocrine organs and hormones during sports activities in men.

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Section: Introductionunclassified

The impact of physical exercise on the endocrine system in men: A review

Berkovskaya,

Elmurzaeva,

Edaev

et al. 2024

Consilium Medicum

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Maternal separation as early-life stress: Mechanisms of neuropsychiatric disorders and inspiration for neonatal care

Zhang,

Wang,

Hei

2024

Brain Research Bulletin

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Neurotrophic Hypothesis of Development of Depression

Yasenyavskaya,

Tsibizova,

Samotrueva

2024

Fiziologiâ čeloveka

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Currently, depression is a widespread mental disorder in modern society and is associated with significant impairments in the quality of life of patients. The review examines the main representatives of neurotrophic factors belonging to various families, in particular nerve growth factor, transforming growth factor beta, neurokines and non-neuronal factors. Neurotrophins, being large polypeptides, play an integrative role, fulfilling the signaling mission of intermediaries in a wide range of physiological processes. At the moment, a large number of studies have been carried out in order to understand the interaction between factors of various directions, including biological, psychological and environmental factors that determine the etiopathogenesis of this pathology. Based on the data obtained, one of the main hypotheses for the development of depression is considered - neurotrophic, which most fully explains the emerging pathogenetic changes. According to this hypothesis, the leading role in the etiology of depression is played by neurotrophic factors that ensure the maintenance of normal neuron-glial interaction, the processes of neurogenesis, angiogenesis, and synaptic plasticity. Neurotrophins have a high physiological activity due to the presence of several binding groups for different cell receptors and the regulatory ability to express other signaling molecules, the ability to penetrate the blood-brain barrier, showing trophic, anti-inflammatory, growth, mediator and effector properties. To date, the mechanisms of the onset of depression, despite the widespread prevalence of this pathology, remain largely unclear, hindering a directed search for targets for the development of effective therapy. The revealed disorders of neurotrophic factors in depression make it reasonable to consider neurotrophins as therapeutic agents in a multitarget approach to the treatment of depressive disorders.

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Molecular Mechanisms Underlying Stress Response and Resilience

Abstract: A variety of stressors induce various physiological responses by modulating sympathetic, neuroendocrine, and behavioral systems [...]

Cited by 3 publications

References 12 publications

The impact of physical exercise on the endocrine system in men: A review

The impact of physical exercise on the endocrine system in men: A review

Maternal separation as early-life stress: Mechanisms of neuropsychiatric disorders and inspiration for neonatal care

Neurotrophic Hypothesis of Development of Depression

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