Molecular mechanisms regulating wound repair: Evidence for paracrine signaling from corneal epithelial cells to fibroblasts and immune cells following transient epithelial cell treatment with Mitomycin C

Pal‐Ghosh, Sonali; Karpinski, Beverly A.; Majumdar, Himani Datta; Ghosh, Trisha; Julie, Thomasian; Stephen, R. Brooks; Andrew, P. Sawaya; Maria, I. Morasso; Kaitlin, K. Scholand; Paiva, Cintia S. de; Jeremias, G. Galletti; Stepp, Mary Ann

doi:10.1016/j.exer.2022.109353

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…Additionally, these stromal stem cells interact closely with corneal epithelial cells [93]. Paracrine signaling between stromal and epithelial cells plays a crucial role in maintaining the health and transparency of the cornea [94,95]. Stromal cells provide essential growth factors and extracellular matrix components that support the survival and functionality of the corneal epithelium.…”

Section: Interactions Within the Stromal Stem Cell Nichementioning

confidence: 99%

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Volatier,

Cursiefen,

Notara

2024

Cells

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Corneal stromal stem cells (CSSCs) are of particular interest in regenerative ophthalmology, offering a new therapeutic target for corneal injuries and diseases. This review provides a comprehensive examination of CSSCs, exploring their anatomy, functions, and role in maintaining corneal integrity. Molecular markers, wound healing mechanisms, and potential therapeutic applications are discussed. Global corneal blindness, especially in more resource-limited regions, underscores the need for innovative solutions. Challenges posed by corneal defects, emphasizing the urgent need for advanced therapeutic interventions, are discussed. The review places a spotlight on exosome therapy as a potential therapy. CSSC-derived exosomes exhibit significant potential for modulating inflammation, promoting tissue repair, and addressing corneal transparency. Additionally, the rejuvenation potential of CSSCs through epigenetic reprogramming adds to the evolving regenerative landscape. The imperative for clinical trials and human studies to seamlessly integrate these strategies into practice is emphasized. This points towards a future where CSSC-based therapies, particularly leveraging exosomes, play a central role in diversifying ophthalmic regenerative medicine.

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Section: Interactions Within the Stromal Stem Cell Nichementioning

confidence: 99%

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Volatier,

Cursiefen,

Notara

2024

Cells

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“…Scars are fibrous tissues formed during the wound-healing process, primarily produced by fibroblasts. By altering the activity and proliferation of fibroblasts, scar formation can be suppressed; for example, with common antifibrotic drugs such as mitomycin C and 5-fluorouracil (5-FU) [ 244 ]. Hongmei Zhang et al designed a dendritic mesoporous bioactive glass nanoparticle (dMBG) loaded with 5-fluorouracil (5-Fu), coaxially electrospun with polyethylene oxide (PEO)-poly(ether-ester-urethane) urea (PEEUU) shell–composite nanofibers ((F@B)/P)@PU), which exhibited antiproliferative activity by inhibiting the growth of HeLa cells.…”

Section: Application Of Nanofibrous Scaffolds In Wound Healingmentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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Molecular mechanisms regulating wound repair: Evidence for paracrine signaling from corneal epithelial cells to fibroblasts and immune cells following transient epithelial cell treatment with Mitomycin C

Cited by 2 publications

References 74 publications

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

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