Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells

Wu, Chenguang; Hong, Chunlan; Klauck, Sabine M.; Lin, Yun‐Lian; Efferth, Thomas

doi:10.1016/j.jep.2015.10.020

Cited by 44 publications

(33 citation statements)

References 79 publications

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“…In HL-60 leukemia cells, RA (50–150 μM) inhibited cell growth and induced apoptosis, which was associated with decreased dNTP levels [104]. CCRF-CEM, CEM/ADR5000 leukemia cells treated with RA (3–100 μM) developed increased cytotoxicity, apoptosis, necrosis, cell cycle arrest and caspase-independent apoptosis which was mediated by increased PARP cleavage and blockage of p65 nuclear translocation [105]. In agreement with other studies, RA (0.07–2.2 mM) exerted DNA protective and anti-carcinogenic effects in HL-60 leukemia cells [106].…”

Section: Anticancer Effects Of Rosmarinic Acid (Ra): In Vitro Studiesmentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action. Rosemary extract has been reported to have antioxidant, anti-inflammatory, antidiabetic and anticancer properties. Rosemary extract contains many polyphenols with carnosic acid and rosmarinic acid found in highest concentrations. The present review summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of rosemary extract and the rosemary extract polyphenols carnosic acid and rosmarinic acid, and their effects on key signaling molecules.

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Section: Anticancer Effects Of Rosmarinic Acid (Ra): In Vitro Studiesmentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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“…Rosmarinic acid (RosA) is an ester of caffeic acid with many biological properties (Petersen & Simmonds, 2003). Increasing evidence shows that RosA exerts antiinflammatory, anti-cancer and antioxidant effects (Wu et al, 2015;Cao et al, 2016;Jin et al, 2017;Eftekhar et al, 2018). Recently, RosA was identified as a potential complementary therapeutic agent in OA treatment (Connelly, 2014).…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effects of rosmarinic acid on catabolism induced by IL-1β in rat chondrocyte

Huang

Chen

2018

Acta Biochim Pol

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The effects of rosmarinic acid (RosA) on osteoarthritis (OA) was investigated in rat chondrocytes. Chondrocytes were isolated from rat cartilage, incubated with RosA in the presence of interleukin-1beta (IL-1β) (10 ng/ml). The production of IL-6, as well as the mRNA level of aggrecan (ACAN) and collagen 2 (COL2), were assessed. The gene and protein expression of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, ADAMTS-5 were also measured. RosA inhibited the production of IL-6 as well as the gene and protein expression of ADAMTS-4 and ADAMTS-5, in addition, RosA abolished IL-1β-induced inhibition of ACAN and COL2 gene expression. Our results suggest that RosA can inhibit extracellular matrix (ECM) degradation in OA, thus, RosA may be a possible agent in the treatment of OA.

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“…Numerous biological activities of RA are demonstrated in many studies such as antioxidative, antiinflammatory, neuroprotective, antitumor, antiallergic and antibacterial 10 -15 . It exerts antiproliferative activity through induction of cell cycle arrest in G 0 /G 1 and G 1 /S phase 16 and induces apoptosis in cancer cells via mitochondrial pathway 17 . In addition, it has antiangiogenic activity 18 .…”

Section: Manymentioning

confidence: 99%

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2018

IJPSR

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The present study aimed to investigate the anticancer effect of rosmarinic acid (RA), both alone and in combination with cisplatin (cis). Also, the potential nephroprotective effects of RA against cis-induced nephrotoxicity in mice and the possible mechanisms underlying this protection were explored. Treatment of HepG2 cells with RA produced a significant decline in cellular proliferation. RA induced cell cycle arrest at G 0 / G 1 phase and S phase, significantly inhibited vascular endothelial growth factor (VEGF) concentration and induced caspase-3 level in cell lysate. While pre-treatment with IC 50 RA before cis addition significantly enhanced cis cytotoxic activity in HepG2 cells. Moreover, Pre-treatment with RA significantly mitigated cis-induced elevation of blood urea nitrogen (BUN) and serum creatinine levels. The elevated levels of malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), Bax and caspase-9 in kidney tissues were significantly reversed. Additionally, RA significantly abrogated cis-induced reduction in reduced glutathione level (GSH). The histopathological examination emphasized the obtained results. Conclusion: RA possesses cytotoxic activity against HepG2 cell line through cell cycle arrest, induction of caspase-3 and inhibition of VEGF. In addition, RA enhances cis-induced cytotoxicity in HepG2 cells. Also, it ameliorates cis-induced nephrotoxicity in mice; an effect which could be attributed to inhibition of oxidative stress, inflammation and apoptosis.

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Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells

Cited by 44 publications

References 79 publications

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

The inhibitory effects of rosmarinic acid on catabolism induced by IL-1β in rat chondrocyte

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