The inhibitory effects of rosmarinic acid on catabolism induced by IL-1β in rat chondrocyte

Hu, Zhong-Nan; Huang, Lijuan; Chen, Wei-Ping

doi:10.18388/abp.2018_2607

Cited by 11 publications

(14 citation statements)

References 25 publications

(25 reference statements)

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“…The treatment also activated extracellular signal-regulated kinase (ERK)-1/2 and p38 kinase signaling pathways [117]. Similar results were observed in rat IL-1β-stimulated chondrocytes, where IL-6 production was inhibited, as well as the gene and protein expression of ADAMTS-4, ADAMTS-5, aggrecan (ACAN), and type II collagen, overall suggesting, as previously observed, that rosmarinic acid could inhibit extracellular matrix (ECM) degradation in OA [118].…”

Section: Rosmarinic Acidsupporting

confidence: 79%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

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The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.

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Section: Rosmarinic Acidsupporting

confidence: 79%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

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“…The inflammatory cytokine interleukin-1-beta (IL-1b) also exerts an important role in ECM degradation (Tu et al, 2017). An effect of RosA on OA has been reported in rat chondrocytes (Hu et al, 2018). In this experiment, chondrocytes were isolated from rat cartilage and incubated with RosA in the presence of IL-1b.…”

Section: Effect Of Rosmarinic Acid On Inflammatory Diseases Arthritismentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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“…In addition, rosmarinic activated the ERK-1/2 and p38 kinase signaling pathways [ 80 ]. In another study on IL-1β-induced rat chondrocytes, rosmarinic acid inhibited the production of IL-6, downregulated gene and protein expression of ADAMTS-4 and ADAMTS-5, and abolished the IL-1β-induced inhibition of ACAN and COL2 gene expression [ 81 ].…”

Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Sirše

2022

Life

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Osteoarthritis is a common crippling and degenerative disease resulting in irreversible functional changes due to damage of the cartilage and other tissues of the joint. With limited safe and effective pharmaceutical treatments, the demand and use for alternative therapeutic approaches with symptomatic relief for OA patients have increased. Clinical, pre-clinical, and in vitro studies have demonstrated that polyphenols can exert pain-relieving symptoms coupled with increased functional capacity in OA models. This review will highlight studies carried out in the last five years to define the efficacies and underlying mechanisms in polyphenols such as quercetin, resveratrol, curcumin, epigallocatechin-3-gallate, rosmarinic acid, genistein, ginger, berries, silver fir, pine bark, and Boswellia. Most of these studies indicate that polyphenols exhibit their beneficial roles through regulating changes at the biochemical and molecular levels, inducing or inhibiting various signaling pathways related to inflammation and oxidative stress. Polyphenols have also been implicated in modulating microRNA at the posttranscriptional level to counteract OA pathogenesis.

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The inhibitory effects of rosmarinic acid on catabolism induced by IL-1β in rat chondrocyte

Cited by 11 publications

References 25 publications

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

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