Molecular mechanisms of pelvic organ prolapse influenced by FBLN5 via FOSL1/miR-222/MEIS1/COL3A1 axis

Zhang, Rui; Li, Ya; Zhang, Jin

doi:10.1016/j.cellsig.2023.111000

Cited by 1 publication

(2 citation statements)

References 63 publications

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“…Firstly, Mechanical strain often directly regulate gene expression. When mechanical stretch was applied, normal hUSLs exhibited ROS, apoptosis, and senescence ( 65 ). In vitro experiments had shown that overexpression of FBLN5 could alleviate mechanical strain-induced damage in hUSLF cells by inhibiting FOSL1 expression.…”

Section: Impact Of Biomechanical-biochemical Coupling On Fibroblast F...mentioning

confidence: 99%

“…In vitro experiments had shown that overexpression of FBLN5 could alleviate mechanical strain-induced damage in hUSLF cells by inhibiting FOSL1 expression. However, knocking out FBLN5 could promote the occurrence of pelvic organ prolapse in the PFD model rats by regulating the FOSL1/miR-222/MEIS1/COL3A1 axis ( 65 ). Secondly, lack of effective mechanical strain modeling at present.…”

Section: Impact Of Biomechanical-biochemical Coupling On Fibroblast F...mentioning

confidence: 99%

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Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse

Wu,

Zhang,

et al. 2024

Front. Med.

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Pelvic organ prolapse (POP) is a significant contributor to hysterectomy among middle-aged and elderly women. However, there are challenges in terms of dedicated pharmaceutical solutions and targeted interventions for POP. The primary characteristics of POP include compromised mechanical properties of uterine ligaments and dysfunction within the vaginal support structure, often resulting from delivery-related injuries. Fibroblasts secrete extracellular matrix, which, along with the cytoskeleton, forms the structural foundation that ensures proper biomechanical function of the fascial system. This system is crucial for maintaining the anatomical position of each pelvic floor organ. By systematically exploring the roles and mechanisms of biomechanical-biochemical transformations in POP, we can understand the impact of forces on the injury and repair of these organs. A comprehensive analysis of the literature revealed that the extracellular matrix produced by fibroblasts, as well as their cytoskeleton, undergoes alterations in patient tissues and cellular models of POP. Additionally, various signaling pathways, including TGF-β1/Smad, Gpx1, PI3K/AKT, p38/MAPK, and Nr4a1, are implicated in the biomechanical-biochemical interplay of fibroblasts. This systematic review of the biomechanical-biochemical interplay in fibroblasts in POP not only enhances our understanding of its underlying causes but also establishes a theoretical foundation for future clinical interventions.

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Section: Impact Of Biomechanical-biochemical Coupling On Fibroblast F...mentioning

confidence: 99%

Section: Impact Of Biomechanical-biochemical Coupling On Fibroblast F...mentioning

confidence: 99%

Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse

Wu,

Zhang,

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

Molecular mechanisms of pelvic organ prolapse influenced by FBLN5 via FOSL1/miR-222/MEIS1/COL3A1 axis

Cited by 1 publication

References 63 publications

Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse

Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse

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