Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse
Huaye Wu,
Ling Zhang,
Li He
et al.
Abstract:Pelvic organ prolapse (POP) is a significant contributor to hysterectomy among middle-aged and elderly women. However, there are challenges in terms of dedicated pharmaceutical solutions and targeted interventions for POP. The primary characteristics of POP include compromised mechanical properties of uterine ligaments and dysfunction within the vaginal support structure, often resulting from delivery-related injuries. Fibroblasts secrete extracellular matrix, which, along with the cytoskeleton, forms the stru… Show more
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