Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo

Yang, Jun; Qin, Hanjun; Chai, Yu; Zhang, Ping; Chen, Yirong; Yang, Kè; Qin, Min; Han, Min; Xia, Hong; Ren, Ling; Yu, Bin

doi:10.1016/j.jot.2020.10.004

Cited by 32 publications

(22 citation statements)

References 34 publications

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“…The authors attributed these results to the preferential adhere of bacteria to the a phase compared with the b phase or Ti 2 Cu region (Peng et al, 2018). Subsequently, they compared the time-effect relationship of biofilm formation by S. aureus on the surface of Ti6Al4V-6.5Cu and Ti6Al4V alloys and found that the former can slow down the adhesion of bacteria on the surface of the material, accelerate the aging of the biofilm, and inhibit biofilm formation (Yang et al, 2021). Zhuang et al (2021) investigated the antibacterial performance of a Ti6Al4V-Cu alloy against MRSA using plate counting and found an antibacterial rate of…”

Section: Applications Of Common Antibacterial Metals and Alloys In Iai Antibacterial Ti Alloymentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

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Section: Applications Of Common Antibacterial Metals and Alloys In Iai Antibacterial Ti Alloymentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Copper (Cu) is a unique metal that is not only a commonly used alloying element in metals but also an essential trace metal element in human body that plays important roles in maintaining human health. It is noteworthy that Cu can regulate the expression of related genes in the process of angiogenesis and bone remodeling [ 18 , 19 ]. Relevant study [ 20 ] showed that, compared with bare Ti6Al4V alloy, a Cu-rich diamond-like (Cu/a-C: H) film coated on Ti6Al4V alloy surface could significantly up-regulate the expressions of vascular endothelial cell growth factor (VEGF), alkaline phosphatase (ALP), osteocalcin (OCN) and other growth factors, which expressively promoted the proliferation of vascular cells and enhanced osteogenic activity in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats

Zhang¹,

Liu²,

et al. 2022

Regenerative Biomaterials

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Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture (OPF). However, the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to loosening. Thus, a new class of Cu-alloyed titanium (TiCu) alloys with excellent mechanical properties and bio-functionalization have been developed. In this study, the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of TiCu. The results showed that after implantation for 4 weeks, TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor (VEGF) expression. After 8 weeks, it could further promote the proliferation and differentiation of osteoblasts, mineralization and deposition of collagens, and then significantly increasing bone mineral density (BMD) around the implant. In conclusion, TiCu alloy would enhance the fixation stability, accelerate the osteointegration, and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis environment. This study was the first to report the role and mechanism of a Cu alloyed metal in promoting osteointegration in osteoporosis environment, which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys.

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“…Recent studies have confirmed the potential antibacterial behavior of Au, Cu, Zn, Ag additions to Ti-based films [16,17]. The biocidal performance of Cu is linked to the release of Cu +1 and Cu +2 ions, as observed in TiCu [18,19]. Recently, Cu-based systems have also been proposed engineer surfaces with antiviral properties, also in the framework of the COVID-19 pandemic [20].…”

Section: Introductionmentioning

confidence: 88%

Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering

Rashid¹,

Vita²,

Persichetti³

et al. 2021

Preprint

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Mechanical robustness, biocompatibility, and antibacterial performances are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering on Si substrates. The thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) thin films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag, we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloy display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.

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Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo

Cited by 32 publications

References 34 publications

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats

Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering

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