Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex

Fujihara, Mitsuhiro; Muroi, Masashi; Tanamoto, Ken‐ichi; Suzuki, Tomohiko; Azuma, Hiroshi; Ikeda, Hisami

doi:10.1016/j.pharmthera.2003.08.003

Cited by 491 publications

(410 citation statements)

References 228 publications

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“…In addition to all of these effects, the LPS is mitogenic for B lymphocytes, which causes degranulation of mast cells and activates macrophages, which also will release a series of chemical mediators 30 .…”

Section: Etiology Of Periapical Lesions and The Role Of Endotoxin In mentioning

confidence: 99%

“…MIF-deficient mice were hyporesponsive to LPS and to Gram-negative bacteria, and also showed resistance to septic shock. Additionally, it has been demonstrated that MIF-deficient macrophages exhibited a significant reduction in the activation of Nuclear Factor-κB (NF-κB) and in the production of TNF-α 30 .…”

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

“…This receptor plays an important role in cellular signaling through the potentialization of adhesion and leukocyte activation, including primary functions, such as the phagocytosis and the production of inflammatory cytokines mediated by LPS 30 .…”

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

“…Obtaining new knowledge on this process has been directed to the identification of molecules belonging to the receptor complex, which plays essential roles in sensitization, binding, and triggering responses to LPS 30 .…”

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

“…30 Although MD-2 does not have a transmembrane domain, this protein remains associated with the cell through its interaction with the extracellular end of TLR4 30,38 .…”

Section: Role Of Myeloid Differentiation Protein-2 (Md-2) In the Recementioning

confidence: 99%

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Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activation

Lucisano

Filho

Silva

et al. 2014

RGO, Rev. Gaúch. Odontol.

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Periapical lesions are diseases resulting from contamination and necrosis of dental pulp and the progression of this infection toward the periapical tissues. Technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, are RESUMOAs lesões periapicais são patologias resultantes da contaminação e necrose da polpa dental e progressão da infecção em direção aos tecidos periapicais. Os avanços tecnológicos na cultura e identificação microbiana demonstraram que, em canais radiculares de dentes portadores de necrose pulpar e lesão periapical crônica, predominam os microrganismos anaeróbios, particularmente os Gram-negativos. As bactérias Gram-negativas, além de possuírem diferentes fatores de virulência e gerarem produtos e subprodutos tóxicos aos tecidos apicais e periapicais, contêm a endotoxina em sua parede celular. Esse conhecimento é importante, uma vez que a endotoxina é liberada durante a multiplicação ou morte bacteriana, exercendo uma série de efeitos biológicos relevantes, que conduzem a uma reação inflamatória e à reabsorção dos tecidos mineralizados. Sendo assim, o objetivo deste trabalho foi efetuar uma revisão da literatura relativa ao papel da endotoxina bacteriana na etiologia das lesões periapicais, seu mecanismo de ação, bem como elucidar mecanismos moleculares envolvidos no seu reconhecimento pelo sistema imunológico e na ativação celular. Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activationPapel da endotoxina na etiologia da lesão periapical: mecanismos moleculares envolvidos no seu reconhecimento e na ativação celular

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Section: Etiology Of Periapical Lesions and The Role Of Endotoxin In mentioning

confidence: 99%

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

“…30 Although MD-2 does not have a transmembrane domain, this protein remains associated with the cell through its interaction with the extracellular end of TLR4 30,38 .…”

Section: Role Of Myeloid Differentiation Protein-2 (Md-2) In the Recementioning

confidence: 99%

See 3 more Smart Citations

Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activation

Lucisano

Filho

Silva

et al. 2014

RGO, Rev. Gaúch. Odontol.

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Phagocytosis: Early Events in Particle Recognition and Uptake

Cosı́o

Grinstein

2009

Intracellular Niches of Microbes

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Development of Imidazoline‐2‐Thiones Based Two‐Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co‐Culture System

Heo

Kim

et al. 2015

Angewandte Chemie

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We designed and prepared the imidazoline‐2‐thione containing OCl− probes, PIS and NIS, which operate through specific reactions with OCl− that yield corresponding fluorescent imidazolium ions. Importantly, we demonstrated that PIS can be employed to image OCl− generation in macrophages in a co‐culture system. We have also employed two‐photon microscopy and PIS to image OCl− in live cells and tissues, indicating that this probe could have wide biological applications.

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Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex

Cited by 491 publications

References 228 publications

Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activation

Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activation

Phagocytosis: Early Events in Particle Recognition and Uptake

Development of Imidazoline‐2‐Thiones Based Two‐Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co‐Culture System

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