Molecular Mechanisms of Inflammation-Induced Carcinogenesis

Okada, Futoshi; Fujii, Junichi

doi:10.3164/jcbn.39.103

Cited by 11 publications

(10 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these three factors, infection/inflammation is definitely involved in carcinogenesis. 18 Although acute inflammation is part of the host's defense to environmental stimuli, chronic inflammation can be an important factor in the development of cancer. 19,20 Almost all tumors are associated with inflammatory cells.…”

Section: Oral Squamous Cell Carcinoma and Dental Implantsmentioning

confidence: 99%

Evaluation of the Effects of Dental Implants on Oral Lesions

Agha‐Hosseini¹,

Rohani²

2015

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

show abstract

Section: Oral Squamous Cell Carcinoma and Dental Implantsmentioning

confidence: 99%

Evaluation of the Effects of Dental Implants on Oral Lesions

Agha‐Hosseini¹,

Rohani²

2015

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

show abstract

“…89 The level of thymosin ß4 gene, which is known as an actin-regulating protein and to function for angiogenesis and wound healing, 90 was elevated in all of the arising tumor cells. From the results of sense and antisense cDNA transfection experiments, we determined that thymosin ß4 gene was responsible for tumor metastasis through regulating cell motility.…”

Section: Experimental Models Of Foreign-body-induced Carcinogenesis Amentioning

confidence: 99%

Beyond foreign‐body‐induced carcinogenesis: Impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression

Okada

2007

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Foreign-body-induced carcinogenesis is a traditional, maybe old, way of understanding cancer development. A number of novel approaches are available today to elucidate cancer development. However, there are things we learn from the old, and thus I bring out some examples of various clinical cases and experimental models of foreign-body-induced tumorigenesis. What is notable is that the foreign bodies themselves are unrelated to each other, whereas commonly underlying in them is to induce inflammatory reaction, especially stromal proliferation, where those exogenous materials are incorporated and undigested. Such foreign-body-induced carcinogenesis is also recognized in the step of tumor progression, the final step of carcinogenesis that tumor cells acquire malignant phenotypes including metastatic properties. And the phenomenon is universally observed in several cell lines of different origins. In this review I would like to show the evidence that tumor development and progression are accelerated inevitably by inflammation caused from foreign bodies, and that reactive oxygen species derived from inflammatory cells are one of the most important genotoxic mediators to accelerate the process. ' 2007 Wiley-Liss, Inc.

show abstract

“…Many diseased states including cancer and cardiovascular disease [1,2] and some of the deficits of age-related neuronal function [3] are associated with an oxidative and inflammatory stress imbalance. Consumption of plant-based foods, rich in antioxidant and anti-inflammatory compounds is considered to be a potentially protective factor and regular intake of fruits and vegetables is known to markedly decrease the risk of developing certain diseases such as colon cancer [4,5].…”

Section: Introductionmentioning

confidence: 99%

Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications

Russell¹,

Labat²,

Scobbie³

et al. 2007

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Blueberries are a rich source of phenylpropanoid-derived phytochemicals, widely studied for their potential health benefits. Of particular interest for colonic health are the lower molecular weight phenolic acids and their derivatives, as these are the predominant phenolic compounds detected in the colon. Blueberries contained a wide variety of phenolic acids, the majority of which (3371.14 +/- 422.30 mg/kg compared to 205.06 +/- 45.34 mg/kg for the free phenolic acids) were attached to other plant cell-wall components and therefore, likely to become available in the colon. Cytokine-induced stimulation of the inflammatory pathways in colon cells was four-fold up-regulated in the presence of the free phenolic acid fraction. Incubation of the bound phenolic acids with human faecal slurries resulted in qualitative and quantitative differences in the phenolic compounds recovered. The metabolites obtained by incubation with faecal slurries from one volunteer significantly decreased (1.67 +/- 0.69 ng/cm(3)) prostanoid production, whereas an increase (10.78 +/- 5.54 ng/cm(3)) was obtained with faecal slurries from another volunteer. These results suggest that any potential protective effect of blueberry phenolics as anti-inflammatory agents in the colon is a likely result of microbial metabolism. Studies addressing a wide-range of well-characterised human volunteers will be required before such health claims can be fully established.

show abstract

Molecular Mechanisms of Inflammation-Induced Carcinogenesis

Cited by 11 publications

References 92 publications

Evaluation of the Effects of Dental Implants on Oral Lesions

Evaluation of the Effects of Dental Implants on Oral Lesions

Beyond foreign‐body‐induced carcinogenesis: Impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression

Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications

Contact Info

Product

Resources

About